{"id":"3cfd42378278","type":"article","url":"https://hartvaat.nl/2026/02/27/pdgf-b-uit-tubulusepitheel-drijft-nierfibrose-aan/","title":"PDGF-B uit tubulusepitheel drijft nierfibrose aan","title_en":"","category":"chronische nierziekte","category_label":"Nierziekte","professions":["internist"],"tags":[],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(26)00141-9/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(26)00141-9/fulltext","authors":["Barbara Mara Klinkhammer","Eva Miriam Buhl","Tim Caspers","Sidrah Maryam","Dickson W.L. Wong","Michael Goedertier","David Laurin Hölscher","Roman David Buelow","Rafael Kramann","Sikander Hayat","Jürgen Floege","Peter Boor"],"significance":4,"published":"2026-04-10","source_date":"2026-02-27","image":"","kennis":["https://hartvaat.nl/kennis/nierziekte/progressie-nierziekte-mechanisme/","https://hartvaat.nl/kennis/farmacologie/aldosteron-en-raas-farmacologie/"],"congress":"","summary_en":"This Kidney International study demonstrates that tubular epithelial cell-derived PDGF-B creates fibrogenic niches and plays a crucial role in renal fibrosis. This epithelial-mesenchymal communication mechanism offers a potential therapeutic target for chronic kidney disease.","created":"2026-07-03T10:32:44Z","updated":"2026-07-03T13:31:40Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Dit onderzoek in Kidney International toont aan dat PDGF-B afkomstig van tubulusepitheel fibrogene niches creëert en zo een cruciale rol speelt in nierfibrose. Het mechanisme van epitheliale-mesenchymale communicatie biedt een potentieel therapeutisch aangrijpingspunt voor chronische nierziekte.","abstract_original":"Kidney fibrosis is the underlying pathological process of chronic kidney disease, a major global medical challenge. In most diseases, fibrosis-initiating injury affects epithelial cells. However, the fibrosis-executing cells are interstitial mesenchymal cells, particularly fibroblasts, expressing the platelet-derived growth factor (PDGF) receptor β (PDGFR-β). Here, we analyzed the cell-specific functional relevance of the PDGFR-β ligand, PDGF-B, in the cellular crosstalk in kidney fibrosis."}