# Prognose takotsubo-syndroom versus hartfalen op de lange termijn

*geplaatst 2026-03-09 · Hartfalen · ESC heart failure · doi 10.1093/eschf/xvag065 · https://hartvaat.nl/2026/02/27/prognose-takotsubo-syndroom-versus-hartfalen-op-de-lange-termijn/*

Een observationele studie in ESC Heart Failure vergeleek de driejaarsuitkomsten van patiënten met takotsubo-syndroom en hartfalen. De analyse uit een wereldwijd netwerk geeft inzicht in het langetermijnrisico op overlijden, MACE en ventriculaire aritmieën — relevant voor de follow-up van takotsubo-patiënten.

## English: Long-term prognosis in Takotsubo Syndrome compared to Heart Failure: Observations from a global federated research network.

An observational study compared three-year outcomes between patients with Takotsubo syndrome and heart failure using a global research network. The findings inform the long-term prognosis and follow-up requirements for Takotsubo patients.

## Abstract (original, from the publication)

AIMS: To compare long-term outcomes of patients with Takotsubo syndrome (TTS) and heart failure (HF). METHODS AND RESULTS: This retrospective observational study used the TriNetX global federated research network. Adult patients (≥18 years) discharged with a diagnosis of TTS (ICD-10-CM I51.81) or HF (I50.x) between 2018 and 2022 were identified. Primary outcomes were three-year risk of all-cause death, major adverse cardiovascular events (MACE; myocardial infarction or ischemic stroke), and acute HF. Secondary outcomes included myocardial infarction, ischemic stroke, ventricular arrhythmias (ventricular tachycardia), malignant arrhythmias (ventricular fibrillation or cardiac arrest), and new-onset atrial fibrillation (AF). Cox proportional hazards models estimated hazard ratios (HRs) with 95% confidence intervals (CIs) before and after 1:1 propensity score matching (PSM). Subgroup analyses were performed by HF phenotype, age (≥65 vs <65 years), and mental health status. The study included 2,240 patients with TTS (mean age 62.6 ± 17.3 years; 73.7% female) and 265,564 patients with HF (69.3 ± 14.7 years; 45.8% female). After PSM, TTS was associated with a lower risk of acute HF (HR 0.622, 95% CI 0.539-0.717), ventricular arrhythmias (HR 0.637, 95% CI 0.441-0.919), malignant arrhythmias (HR 0.656, 95% CI 0.571-0.754), new-onset AF (HR 0.672, 95% CI 0.517-0.875), and myocardial infarction (HR 0.818, 95% CI 0.687-0.974), with no significant differences in the remaining outcomes. Differences were greater when TTS was compared with heart failure with reduced ejection fraction. CONCLUSION: TTS is associated with lower risk of adverse events than HF. Further research is needed on mental health in its pathogenesis and prognosis.

Auteurs: Enrico Tartaglia, Muath Alobaida, Tommaso Bucci, Michele Rossi, Amir Askarinejad, Ho Man Lam, Mert Kaskal, Andrea Galeazzo Rigutini, Giuseppe Boriani, Gregory Y H Lip

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Bron: ESC heart failure, https://doi.org/10.1093/eschf/xvag065. Bijgewerkt 2026-07-03T18:39:27Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.