{"id":"62ee49bdde87","type":"article","url":"https://hartvaat.nl/2026/02/27/smoothened-signalering-bevordert-nierfibrose-via-autofagieremming/","title":"Smoothened-signalering bevordert nierfibrose via autofagieremming","title_en":"","category":"chronische nierziekte","category_label":"Nierziekte","professions":["internist"],"tags":[],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(26)00140-7/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(26)00140-7/fulltext","authors":["Xiaonan Wang","Ye Liang","Jiemei Li","Xiaoxu Wang","Weijie Zhong","Yabing Xiong","Wenting Ye","Canzhen Liu","Xian Ling","Jinhua Miao","Weiwei Shen","Shan Zhou","Ping Meng","Youhua Liu","Fan Fan Hou","Xiaolong Li","Lili Zhou"],"significance":4,"published":"2026-04-10","source_date":"2026-02-27","image":"","kennis":["https://hartvaat.nl/kennis/nierziekte/progressie-nierziekte-mechanisme/"],"congress":"","summary_en":"Research in Kidney International shows that enhanced Smoothened receptor signalling promotes renal fibrosis by inhibiting autophagy in fibroblasts. This mechanistic insight into the Hedgehog signalling pathway contributes to understanding progressive kidney disease.","created":"2026-07-03T10:32:44Z","updated":"2026-07-03T13:31:40Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Onderzoek in Kidney International laat zien dat verhoogde Smoothened-receptorsignalering nierfibrose bevordert door autofagie in fibroblasten te remmen. Dit mechanistisch inzicht in de Hedgehog-signaleringsroute draagt bij aan het begrip van progressieve nierziekte.","abstract_original":"Kidney fibrosis progressively induces kidney function loss, leading to kidney failure. Myofibroblast transition from fibroblast is significantly involved in the development of kidney fibrosis. Previous studies revealed that sonic hedgehog (Shh), the upstream ligand of Smoothened (Smo) receptor signaling, contributes to kidney fibrosis. However, the role of Smo in fibroblast activation remains unclear."}