{"id":"03d1eb50cdf6","type":"article","url":"https://hartvaat.nl/2026/03/01/histoplasma-capsulatum-een-zeldzame-oorzaak-van-interstitiele-nefritis/","title":"Histoplasma capsulatum: een zeldzame oorzaak van interstitiële nefritis","title_en":"Histoplasma capsulatum: a rare cause of interstitial nephritis","category":"chronische nierziekte","category_label":"Nierziekte","professions":["internist"],"tags":[],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(25)00674-X/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(25)00674-X/fulltext","authors":["Osvaldo Mariano Viana Neto","Elizabeth De Francesco Daher","Mariana Salomão Braga","Lauro Vieira Perdigão Neto","Luis Arthur Brasil Gadelha Farias","Geraldo Bezerra da Silva Júnior","Juliana Reis Machado","Marlene Antônia dos Reis"],"significance":3,"published":"2026-03-01","source_date":"2026-03-01","image":"","kennis":[],"congress":"","summary_en":"A case report of Histoplasma capsulatum as a rare cause of interstitial nephritis in a 46-year-old Brazilian man, presenting with rising creatinine in the context of known interstitial lung disease.","created":"2026-07-03T10:25:16Z","updated":"2026-07-03T13:24:42Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Een 46-jarige Braziliaanse man werd verwezen naar nefrologie wegens stijgend creatinine. Hij werd gevolgd door longartsen voor een interstitieel longbeeld. Histoplasma capsulatum bleek een zeldzame oorzaak van interstitiële nefritis.","abstract_original":"A 46-year-old Brazilian man, smoker with a 10-pack-year history and a social drinker, was referred to nephrology for evaluation of elevated serum creatinine (2.2 mg/dl; baseline 0.9 mg/dl 6 months earlier). He had been followed by pulmonology for an 8-month history of malaise, intermittent fever, unintentional weight loss of 20 kg over 2 months, oral ulcers, and a chest computed tomography showing hilar lymphadenopathy and centrilobular nodules with a tree-in-bud pattern in the left lobe. Bronchofibroscopy with lung biopsy revealed lymphocytes, plasma cells, foamy histiocytes, multinucleated giant cells, and granulomas, with no fungi or mycobacteria (negative Grocott and Fite-Faraco stains), consistent with sarcoidosis."}