{"id":"9e77e78abf99","type":"article","url":"https://hartvaat.nl/2026/03/01/monoklonaal-versus-monotypisch-bewustwording-van-terminologie-bij-mgrs/","title":"Monoklonaal versus monotypisch: bewustwording van terminologie bij MGRS","title_en":"Monoclonal versus monotypic: promoting awareness of terminology and clinical take-aways","category":"chronische nierziekte","category_label":"Nierziekte","professions":["internist"],"tags":[],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(25)01000-2/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(25)01000-2/fulltext","authors":["Sijie Zheng","David J. Iberri","Susan Ziolkowski"],"significance":5,"published":"2026-03-01","source_date":"2026-03-01","image":"","kennis":["https://hartvaat.nl/kennis/farmacologie/betablokkers-farmacologie/"],"congress":"","summary_en":"This commentary highlights the importance of distinguishing monoclonal from monotypic immunoglobulin deposits in proliferative glomerulonephritis, with implications for the classification and management of monoclonal gammopathy of renal significance.","created":"2026-07-03T10:25:15Z","updated":"2026-07-03T13:24:42Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Javaugue et al. benadrukken het belang van klonaliteitsbepaling bij proliferatieve glomerulonefritis met monoklonale Ig-deposities, een subtype van monoklonale gammapathie van renale significantie (MGRS). Dit commentaar bespreekt de terminologische en klinische nuances.","abstract_original":"Javaugue et al. highlight the importance of assessing clonality in patients with proliferative glomerulonephritis with monoclonal Ig deposits, a subtype of monoclonal gammopathy of renal significance (MGRS).1 Whereas MGRS represents kidney injury caused by monoclonal gammopathy,1 the authors demonstrate that most proliferative glomerulonephritis with monoclonal Ig deposits cases lack a demonstrable clone even with sensitive molecular testing. They propose reclassifying proliferative glomerulonephritis with monoclonal Ig deposits as proliferative glomerulonephritis with monotypic Ig deposits."}