{"id":"608a8ff91e16","type":"article","url":"https://hartvaat.nl/2026/03/01/pathologische-diagnostiek-met-moleculaire-monitoring-bij-nierxenotransplantatie/","title":"Pathologische diagnostiek met moleculaire monitoring bij nierxenotransplantatie","title_en":"Pathologic diagnosis incorporating molecular monitoring highlights new pathophysiological mechanisms in kidney xenotransplantation","category":"chronische nierziekte","category_label":"Nierziekte","professions":["internist"],"tags":[],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(25)01040-3/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(25)01040-3/fulltext","authors":["Hisashi Sahara","Akira Shimizu"],"significance":6,"published":"2026-03-01","source_date":"2026-03-01","image":"","kennis":["https://hartvaat.nl/kennis/nierziekte/cardiorenal-syndroom/"],"congress":"","summary_en":"This study used pathologic diagnosis incorporating molecular monitoring to highlight new pathophysiological mechanisms in kidney xenotransplantation, advancing the understanding of long-term graft changes in this emerging field.","created":"2026-07-03T10:25:15Z","updated":"2026-07-03T13:24:41Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Nierxenotransplantatie biedt een oplossing voor het orgaantekort, maar korte klinische observaties geven beperkt inzicht in langetermijnveranderingen. Een geïntegreerd pathologie-moleculair raamwerk combineert biopsiefenotypering, transcriptanalyse en ruimtelijke profilering.","abstract_original":"Kidney xenotransplantation addresses organ shortages; however, short-term clinical observations provide limited insights into long-term graft changes. A pathology–molecular framework integrating biopsy phenotyping, transcript analysis, and spatial profiling can improve the interpretation of long-surviving pig-to-nonhuman primate kidney xenografts. B-HOTX, a xenograft-adapted version of the Banff Human Organ Transplant gene panel, distinguishes donor from recipient transcripts, reducing the misclassification of physiological leukocyte signals as rejection."}