{"id":"9b9cbcc03d17","type":"article","url":"https://hartvaat.nl/2026/03/01/rna-methylering-bij-acuut-nierletsel-nieuwe-therapeutische-mogelijkheden/","title":"RNA-methylering bij acuut nierletsel: nieuwe therapeutische mogelijkheden","title_en":"RNA methylation in acute kidney injury: opening up new therapeutic avenues","category":"chronische nierziekte","category_label":"Nierziekte","professions":["internist"],"tags":[],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(25)01029-4/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(25)01029-4/fulltext","authors":["Volker H. Haase"],"significance":5,"published":"2026-03-01","source_date":"2026-03-01","image":"","kennis":[],"congress":"","summary_en":"This commentary discusses how epithelial methyltransferase-like 1 promotes mitochondrial dysfunction and tubular injury in acute kidney injury through RNA guanosine methylation, identifying a new epigenetic regulatory axis as a potential therapeutic target.","created":"2026-07-03T10:25:15Z","updated":"2026-07-03T13:24:41Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"RNA-methylering is een krachtige regulator van cellulaire processen. Xie et al. tonen aan dat epitheliaal methyltransferase-like 1 via guanosinemethylering de stressrespons bij acuut nierletsel beïnvloedt, wat nieuwe therapeutische aangrijpingspunten opent.","abstract_original":"RNA methylation has emerged as a potent regulator of multiple cellular processes, including stress responses, metabolism, growth, and differentiation. Xie et al. demonstrate that epithelial methyltransferase-like 1, which methylates RNA guanosine residues, promotes mitochondrial dysfunction, tubular injury, and inflammation in acute kidney injury. The authors propose a model by which methyltransferase-like 1 increases the activity of TEA domain transcription factor 2 through methylation, identifying the methyltransferase-like 1/TEA domain transcription factor 2 axis as a potential therapeutic target for renoprotection."}