{"id":"9bbd9491d2cb","type":"article","url":"https://hartvaat.nl/2026/03/02/aorta-en-iliacale-calcificaties-voorspellen-dissectie-aneurysmaruptuur-en-perife/","title":"Aorta- en iliacale calcificaties voorspellen dissectie, aneurysmaruptuur en perifeer vaatlijden","title_en":"Aortic and Iliac Calcifications as Predictors of Aortic Dissection, Aneurysm Rupture, and Peripheral Vascular Disease: A Prospective Cohort Study from the DANCAVAS Trials","category":"algemeen","category_label":"Algemeen","professions":["cardioloog","huisarts","internist"],"tags":["aorta-aneurysma","aortacoarctatie","aortadissectie","aortainsufficiëntie","aortastenose","perifeer-vaatlijden"],"journal":"Circulation","doi":"https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.076240","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.076240","authors":["Cecilie Skov Petersen"],"significance":7,"published":"2026-03-19","source_date":"2026-03-02","image":"","kennis":["https://hartvaat.nl/kennis/cardiometabool/inflammatie-en-atherosclerose/","https://hartvaat.nl/kennis/kleplijden/aortastenose/"],"congress":"","summary_en":"This prospective cohort study showed that aortic and iliac calcifications on CT predict aortic dissection, aneurysm rupture, and peripheral vascular events, establishing vascular calcification as a marker for acute aortic complications.","created":"2026-07-03T10:32:36Z","updated":"2026-07-03T13:31:32Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Deze prospectieve cohortstudie uit de DANCAVAS-trials onderzocht of aorta- en iliacale calcificaties op CT aortadissectie, aneurysmaruptuur en perifeer vaatlijden voorspellen. De populatiegebaseerde data tonen dat calcificatiescores een bruikbare risicostratificatie bieden voor deze ernstige vasculaire events.","abstract_original":"BACKGROUND:There is limited evidence of the relationship between aortic and iliac calcification and aortic events (aortic dissection or aneurysm rupture) and major adverse limb events (MALEs; peripheral revascularization and lower limb amputation). The aim of this population-based prospective cohort study was to investigate the association of aortic and iliac calcifications with aortic events and MALEs.METHODS:All participants from the DANCAVAS (Danish Cardiovascular Screening) trials who received a full thoracoabdominal aortic computed tomography scan with recorded measurements of aortic and iliac calcification were included. The aorta and iliac artery calcifications were measured in a 5-segment model and categorized into quartiles, apart from the ascending aorta, which was categorized into 4 exposure groups, as the majority of participants had no calcification in the ascending aorta. The participants were followed from inclusion in the DANCAVAS trial until aortic events, MALE, death,"}