{"id":"8a969e807cb8","type":"article","url":"https://hartvaat.nl/2026/03/02/extracellulaire-vesikels-medieren-adipocyt-cardiomyocytcommunicatie-bij-diabetis/","title":"Extracellulaire vesikels mediëren adipocyt-cardiomyocytcommunicatie bij diabetisch ischemisch hartfalen","title_en":"","category":"algemeen","category_label":"Algemeen","professions":["cardioloog","internist"],"tags":["acuut-hartfalen","diabetes-en-hart","diabetes-type-1","diabetes-type-2","ezetimibe","myocardinfarct","obesitas","perifeer-vaatlijden","richtlijnen-esc","select-trial","soul-trial","vrouwen"],"journal":"Circulation","doi":"https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.076372","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.076372","authors":["Zhen Zhang"],"significance":5,"published":"2026-03-31","source_date":"2026-03-02","image":"","kennis":["https://hartvaat.nl/kennis/farmacologie/sglt2-remmers-cardiovasculaire-trials/","https://hartvaat.nl/kennis/cardiometabool/cardiometabool-spreekuur/"],"congress":"","summary_en":"This Circulation study demonstrates that small extracellular vesicles bearing surface adiponectin play a crucial role in adipocyte-cardiomyocyte communication in diabetic ischaemic heart failure. The findings partly explain why diabetes patients have worse prognosis after myocardial infarction.","created":"2026-07-03T10:32:40Z","updated":"2026-07-03T18:39:29Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Deze Circulation-studie toont aan dat kleine extracellulaire vesikels (sEVs) met adiponectine op het oppervlak een cruciale rol spelen in de communicatie tussen adipocyten en cardiomyocyten bij diabetisch ischemisch hartfalen. De bevindingen verklaren deels waarom diabetespatiënten een slechtere prognose hebben na een myocardinfarct.","abstract_original":"BACKGROUND:Mortality from acute myocardial infarction (MI) has declined significantly in the past decade for nondiabetic patients. However, both morbidity and mobility of ischemic heart failure (IHF) persistently escalate in the diabetic population via incompletely understood mechanisms. Recent studies demonstrated that small extracellular vesicles (sEVs) released from nondiabetic and diabetic adipocytes (ADps) exert opposite effects on acute myocardial ischemia and reperfusion (MI/R) injury. However, whether and how ADp sEVs may protect against post-MI remodeling and IHF, and more important, whether and how diabetes may impair this protective effect, remain unknown.METHODS:sEVs were isolated from epididymal fat pads of nondiabetic animals and intramyocardially injected in nondiabetic or diabetic hearts subjected to MI (90 minutes of MI per 4 weeks of reperfusion).RESULTS:sEV treatment significantly attenuated post-MI cardiac remodeling and improved cardiac function in nondiabetic mice"}