{"id":"092a3d81e566","type":"article","url":"https://hartvaat.nl/2026/03/03/darmmicrobioom-bevordert-atriumfibrilleren-bij-chronische-nierziekte-via-nlrp3-i/","title":"Darmmicrobioom bevordert atriumfibrilleren bij chronische nierziekte via NLRP3-inflammasoom","title_en":"","category":"chronische nierziekte","category_label":"Nierziekte","professions":["cardioloog","internist"],"tags":["anemie-ckd","atriale-cardiomyopathie","cardiorenal-behandelstrategie","chronische-nierziekte","gedilateerde-cardiomyopathie","inflammatie","laminopathie","microbioom"],"journal":"Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology","doi":"10.1093/europace/euag037","source_url":"https://doi.org/10.1093/europace/euag037","authors":["Xuejie Han","Hui Yu","Qianhui Gao","Xiaoyu Wang","Linwei Zhang","Qian Zhao","Luyang Yu","Yun Zhang","Manshu Sui","Yue Li"],"significance":5,"published":"2026-04-07","source_date":"2026-03-03","image":"","kennis":["https://hartvaat.nl/kennis/nierziekte/nierziekte-en-cardiovasculair-risico/","https://hartvaat.nl/kennis/cardiometabool/obesitas-en-hart/"],"congress":"","summary_en":"Chronic kidney disease increases the risk of atrial fibrillation, but the underlying mechanism is incompletely understood. In a rat model, this study demonstrates that gut microbiome dysbiosis promotes CKD-associated AF via NLRP3 inflammasome activation, opening potential therapeutic avenues at the nephrology-cardiology interface.","created":"2026-07-03T10:32:42Z","updated":"2026-07-03T13:31:39Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Chronische nierziekte verhoogt het risico op atriumfibrilleren, maar het onderliggende mechanisme is onvolledig begrepen. In een ratmodel toont deze studie aan dat dysbiose van het darmmicrobioom CKD-geassocieerd AF bevordert via activatie van het NLRP3-inflammasoom. Deze bevindingen openen mogelijk nieuwe therapeutische aangrijpingspunten op het snijvlak van nefrologie en cardiologie.","abstract_original":"BACKGROUND: Chronic kidney disease (CKD) significantly increases the risk of atrial fibrillation (AF). Although alterations in the gut microbiota have been linked to CKD progression, its exact involvement in CKD-associated AF remians unclear. We amis to investigate the role of gut microbiota in the development of CKD-associated AF, and to uncover potential mechanisms that could serve as effective targets for prevention and treatment. METHODS AND RESULTS: A rat model of CKD was induced by an adenine-enriched diet. 16S rRNA sequencing and fecal microbiota transplantation (FMT) were utilized to study the involvement of gut microbiota. AST-120, gut barrier protectants and mono-colonization experiments were performed to investigate potential mechanism. CKD rats exhibited gut microbiota dysbiosis and a significantly increased susceptibility to AF. FMT from CKD rats transferred this heightened AF susceptibility to healthy recipient rats, linked to the activation of the NLRP3 inflammasome. Mechanistically, gut dysbiosis in CKD patients leads to elevated IS levels, causing gut barrier dysfunction and increased circulating lipopolysaccharide (LPS). Elevated LPS activates atrial TLR4 receptors, triggering NLRP3 inflammasome activation, which contributes to AF pathogenesis. Treatment with the IS scavenger AST-120 or gut barrier protectants successfully prevented CKD-associated AF. Furthermore, supplementation with Lactobacillus gasseri reduced circulating IS levels and mitigated AF susceptibility in CKD rats. CONCLUSION: This study demonstrates that gut dysbiosis-driven elevation of IS and subsequent activation of the atrial NLRP3 inflammasome are key mechanisms in CKD-associated AF. Modulating the gut microbiota could provide a new therapeutic strategy for CKD-associated AF."}