{"id":"c1176c2305d7","type":"article","url":"https://hartvaat.nl/2026/03/03/wereldwijde-toename-atriumfibrilleren-treft-steeds-vaker-jongere-volwassenen/","title":"Wereldwijde toename atriumfibrilleren treft steeds vaker jongere volwassenen","title_en":"","category":"atriumfibrilleren","category_label":"Atriumfibrilleren","professions":["cardioloog","huisarts"],"tags":["gedilateerde-cardiomyopathie","hypertrofische-cardiomyopathie","ouderen","vrouwen"],"journal":"Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology","doi":"10.1093/europace/euag036","source_url":"https://doi.org/10.1093/europace/euag036","authors":["Siyuan Tan","Zixi Zhang","Qiuzhen Lin","Tao Tu","Jiayi Zhu","Gaoming Zeng","Fanqi Li","Kangrong Li","Yongguo Dai","Jiabao Zhou","Cancan Wang","Chan Liu","Yichao Xiao","Qiming Liu"],"significance":6,"published":"2026-03-29","source_date":"2026-03-03","image":"","kennis":["https://hartvaat.nl/kennis/atriumfibrilleren/atriumflutter/","https://hartvaat.nl/kennis/atriumfibrilleren/chadsvasc-score/"],"congress":"","summary_en":"Analysis of Global Burden of Disease 2023 data reveals a rising global incidence of atrial fibrillation and atrial flutter, notably among younger and middle-aged adults, particularly in low- and middle-income countries. Six modifiable risk factors were identified as contributing to AF-related mortality.","created":"2026-07-03T10:32:39Z","updated":"2026-07-03T18:39:29Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Op basis van Global Burden of Disease 2023-data werd de wereldwijde ziektelast van atriumfibrilleren en atriumflutter geanalyseerd van 1990 tot 2023. Opvallend is de stijgende incidentie onder jongere en middelbare leeftijdsgroepen, vooral in landen met een laag en middeninkomen. Zes modificeerbare risicofactoren werden geïdentificeerd als bijdragend aan de AF-gerelateerde mortaliteit.","abstract_original":"BACKGROUND: The burden of atrial fibrillation and atrial flutter (AF/AFL) has increased, but age-specific patterns across World Bank income levels (WBILs) remain unclear. METHODS: Using the Global Burden of Disease 2023 estimates, we assessed age- and WBIL-stratified trends in prevalence, incidence, mortality, and disability-adjusted life years (DALYs) for AF/AFL from 1990 to 2023, employing age-period-cohort analysis and joinpoint regression. Mortality attributable to six modifiable risk factors was quantified based on comparative risk assessment estimates. Projections of AF/AFL burden for 2024-2048 were generated using Bayesian age-period-cohort models. RESULTS: In 2023, AF/AFL affected 58.99 million prevalent cases, 5.02 million incident cases, 376862 deaths, and 9.26 million DALYs, with the absolute burden concentrated in adults aged ≥ 65 years. From 1990 to 2023, age-standardized prevalence (ASPR) and incidence rate (ASIR) increased, while mortality rate (ASMR) and disability-adjusted life year rate (ASDR) remained stable. High-income countries showed increases across all metrics, upper-middle-income countries had rising ASPR/ASIR and decreasing ASMR/ASDR, and lower-middle- and low-income countries showed consistent increases across all metrics. Among younger (30-44 years) and middle-aged (45-64 years) adults, all metrics increased, while in older adults, only ASPR rose. High systolic blood pressure was the leading attributable risk factor, with larger contributions from high body mass index, smoking, and alcohol use in younger and middle-aged adults. Projections indicated modest declines in ASPR, stable ASIR, and increasing ASMR/ASDR through 2048. CONCLUSIONS: Despite the concentrated burden in older adults, mortality- and disability-related burden is rising in younger and middle-aged populations, with significant variation across WBILs."}