{"id":"6c3eab5cac51","type":"article","url":"https://hartvaat.nl/2026/03/04/veroudering-immuundysfunctie-en-nierfibrose-kip-of-ei/","title":"Veroudering, immuundysfunctie en nierfibrose: kip of ei?","title_en":"","category":"chronische nierziekte","category_label":"Nierziekte","professions":["internist"],"tags":["anemie-ckd","chronische-nierziekte"],"journal":"Kidney International","doi":"https://www.kidney-international.org/article/S0085-2538(25)00950-0/fulltext","source_url":"https://doi.org/https://www.kidney-international.org/article/S0085-2538(25)00950-0/fulltext","authors":["David P. Baird","David A. Ferenbach"],"significance":5,"published":"2026-04-05","source_date":"2026-03-04","image":"","kennis":["https://hartvaat.nl/kennis/nierziekte/progressie-nierziekte-mechanisme/","https://hartvaat.nl/kennis/nierziekte/nsaids-en-nierziekte/"],"congress":"","summary_en":"Ageing is a major risk factor for chronic kidney disease, with renal fibrosis as a central feature. This review examines the interplay between immune system ageing, epithelial senescence, and fibrotic changes in the kidney, seeking therapeutic targets for age-related CKD.","created":"2026-07-03T10:32:42Z","updated":"2026-07-03T13:31:38Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Veroudering is een belangrijke risicofactor voor chronische nierziekte, waarbij nierfibrose centraal staat. Deze review beschrijft de wisselwerking tussen immuunsysteemveroudering, epitheliale senescentie en fibrotische veranderingen in de nier. Het ontrafelen van deze kip-ei-vraag kan leiden tot nieuwe therapeutische aangrijpingspunten voor leeftijdsgerelateerde CKD.","abstract_original":"Aging is a significant risk factor for the development of chronic kidney disease (CKD), an incurable condition that can progress despite current “standard of care” treatments. Multiple transcriptional and histologic changes are shared by “normal aged” and CKD kidneys. These include increased myofibroblast number, interstitial collagen deposition, chronic immune infiltrates, and increased levels of renal epithelial senescence (senescent cells [SCs], permanently growth-arrested cells with altered behavior, and secretory phenotypes) compared with healthy young kidneys."}