{"id":"892e87dff836","type":"article","url":"https://hartvaat.nl/2026/03/05/trem-1-remming-vermindert-in-stent-neoatherosclerose-in-diermodel/","title":"TREM-1-remming vermindert in-stent neoatherosclerose in diermodel","title_en":"","category":"cholesterol","category_label":"Cholesterol","professions":["cardioloog"],"tags":[],"journal":"Atherosclerosis","doi":"https://www.atherosclerosis-journal.com/article/S0021-9150(26)00067-5/fulltext","source_url":"https://doi.org/https://www.atherosclerosis-journal.com/article/S0021-9150(26)00067-5/fulltext","authors":["Mengting Jiang","Yingqian Zhang","Xiaohang Yuan","Yuxing Chen","Yan Han","Xietian Pan","Xi Zhang","Haoyi Ye","Wei Wang","Wei Tong","Lei Gao"],"significance":4,"published":"2026-04-12","source_date":"2026-03-05","image":"","kennis":["https://hartvaat.nl/kennis/lipiden/lpa-meten-wanneer-waarom/"],"congress":"","summary_en":"In-stent neoatherosclerosis contributes to late stent thrombosis and restenosis. This study investigated pharmacological TREM-1 inhibition with nangibotide (LR12) in a rabbit model and found favourable effects on neoatherosclerosis development via macrophage polarisation modulation, identifying a potential therapeutic target.","created":"2026-07-03T10:32:44Z","updated":"2026-07-03T13:31:40Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"In-stent neoatherosclerose draagt bij aan late stenttrombose en restenose. In een konijnenmodel onderzocht deze studie het effect van farmacologische remming van de ontstekingsmediator TREM-1 met nangibotide (LR12) op de ontwikkeling van neoatherosclerose. OCT-metingen toonden een gunstig effect via modulatie van macrofaagpolarisatie, wat een nieuw therapeutisch aangrijpingspunt kan zijn.","abstract_original":"In-stent neoatherosclerosis (ISNA) contributes significantly to late stent thrombosis and in-stent restenosis. Triggering receptor expressed on myeloid cells-1 (TREM-1) is a key amplifier of inflammation; however, its role in ISNA pathogenesis remains unexplored. In this study, we investigated the effects of pharmacologically inhibiting TREM-1 with a novel clinical agent LR12 (nangibotide) on ISNA development in an experimental model."}