{"id":"820b2a46271d","type":"article","url":"https://hartvaat.nl/2026/03/18/systematische-review-welke-factoren-voorspellen-langetermijnrisico-op-beroerte-n/","title":"Systematische review: welke factoren voorspellen langetermijnrisico op beroerte na TIA of kleine beroerte?","title_en":"","category":"algemeen","category_label":"Algemeen","professions":["cardioloog","huisarts"],"tags":["primaire-preventie"],"journal":"Circulation","doi":"https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.078763","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.078763","authors":["Faizan Khan"],"significance":7,"published":"2026-04-25","source_date":"2026-03-18","image":"","kennis":["https://hartvaat.nl/kennis/ritmestoornissen/implanteerbare-loop-recorder/","https://hartvaat.nl/kennis/vasculair/ischemische-beroerte-tia/"],"congress":"","summary_en":"This systematic review and meta-analysis of 28 cohort studies (n≈86,000) identifies factors predicting long-term stroke risk after TIA or minor stroke. Pooled hazard ratios and population attribution fractions were estimated. The findings reinforce that TIA carries sustained risk over many years and provide practical targets for secondary prevention focused on vascular risk factors.","created":"2026-07-03T10:32:48Z","updated":"2026-07-03T13:31:44Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Deze systematische review en meta-analyse van 28 cohortstudies (n≈86.000) brengt in kaart welke factoren het langetermijnrisico op een recidiefberoerte na TIA of kleine beroerte voorspellen. De auteurs berekenden gepoolde hazardratios en populatieattributie-fracties. Bevindingen ondersteunen dat TIA een gebeurtenis blijft met jarenlang verhoogd risico en leveren praktische aanknopingspunten voor secundaire preventie op vasculaire risicofactoren.","abstract_original":"BACKGROUND:Patients with a transient ischemic attack (TIA) or minor stroke have an increased risk of subsequent stroke that persists for at least 10 years. We aimed to identify prognostic factors associated with long-term risk of stroke in this patient group and estimate their population attributable fraction (PAF).METHODS:A systematic review was performed of MEDLINE, Embase, and Web of Science for cohort studies including patients with TIA or minor stroke that evaluated factors for subsequent stroke over a follow-up period of ≥1 year. We pooled hazard ratios adjusted for relevant confounders using random-effect meta-analysis and determined the PAF of factors based on their pooled prevalence and adjusted hazard ratio. We assessed certainty of evidence using the grading of recommendations, assessment, development, and evaluation approach. The study is registered in PROSPERO (CRD42023476551).RESULTS:From 14 732 identified citations, we included 28 cohort studies comprising 86 810 patient"}