{"id":"4b8b141e2d52","type":"article","url":"https://hartvaat.nl/2026/03/23/bloeddrukbeloop-vanaf-jongvolwassenheid-voorspelt-leververvetting-op-middelbare-/","title":"Bloeddrukbeloop vanaf jongvolwassenheid voorspelt leververvetting op middelbare leeftijd (CARDIA)","title_en":"Blood Pressure Trajectories in Young Adulthood and Midlife Steatotic Liver Disease","category":"hypertensie","category_label":"Hypertensie","professions":["cardioloog","huisarts","internist"],"tags":["bloeddrukbehandeling"],"journal":"Hypertension","doi":"https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.26319","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.26319","authors":["Yun Chen"],"significance":6,"published":"2026-03-23","source_date":"2026-03-23","image":"","kennis":["https://hartvaat.nl/kennis/hypertensie/wat-is-hypertensie/","https://hartvaat.nl/kennis/hypertensie/cardiovasculaire-risicoschatting-score2/"],"congress":"","summary_en":"High blood pressure is a risk factor for steatotic liver disease (SLD), but whether BP trajectories from young adulthood relate to midlife SLD was unclear. In the US CARDIA cohort (2,817 participants enrolled aged 18-30 in 1985-1986), BP was measured up to eight times over 25 years, with SLD assessed by CT at year 25. Compared with a low-stable diastolic BP trajectory, all other trajectories had higher SLD prevalence, with adjusted relative risks up to 2.02 for the 'elevated-increasing' trajectory; the same held for systolic BP. Those who developed hypertension had a 1.6- to 1.8-fold higher SLD risk, and a faster rate of BP increase carried the highest risk. Long-term BP trajectory in young adulthood is thus independently associated with later-life fatty liver.","created":"2026-07-03T10:32:22Z","updated":"2026-07-03T18:39:23Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Een hoge bloeddruk is een risicofactor voor steatotische leverziekte (SLD), maar of het bloeddrukbeloop vanaf de jongvolwassenheid samenhangt met SLD op middelbare leeftijd was onduidelijk. In het Amerikaanse CARDIA-cohort (2.817 deelnemers, geïncludeerd op 18-30 jaar in 1985-1986) werd de bloeddruk over 25 jaar tot acht keer gemeten, met SLD-meting via CT na 25 jaar. Vergeleken met een laag-stabiel diastolisch bloeddrukbeloop hadden alle andere trajecten een hogere SLD-prevalentie, met gecorrigeerde relatieve risico's tot 2,02 voor het 'verhoogd-stijgende' beloop; ook voor de systolische bloeddruk gold dit. Wie hypertensie ontwikkelde, had een 1,6- tot 1,8-voudig hoger SLD-risico, en een snellere bloeddrukstijging gaf het hoogste risico. Het langetermijnbloeddrukbeloop in de jongvolwassenheid is dus onafhankelijk geassocieerd met leververvetting later in het leven.","abstract_original":"Hypertension, Volume 83, Issue 6, Page e26319, June 1, 2026. BACKGROUND:Although high blood pressure (BP) is a risk factor for steatotic liver disease (SLD), whether longitudinal BP trajectories starting in young adulthood are associated with midlife SLD is unclear.METHODS:We used data from a US-based prospective cohort, the CARDIA study (Coronary Artery Risk Development in Young Adults), which enrolled 5115 Black and White adults aged 18 to 30 years in 1985 to 1986 (Year 0, Y0). Diastolic and systolic BP and hypertension trajectories were evaluated based on up to 8 BP measures over a 25-year follow-up. SLD at Y25 was measured using noncontrast abdominal computed tomography scans.RESULTS:Among 2817 participants included in the analytic sample, 622 SLD cases were identified. Compared with the low-stable diastolic BP group, other trajectories showed higher SLD prevalence (22.0%–37.5% versus 12.8%), with multivariable-adjusted relative risks of 1.47 (95% CI, 1.17–1.84) for moderate-stable, 1.77 (1.33–2.35) for moderate-increasing (remaining below the threshold for hypertension), 1.57 (1.21–2.04) for elevated-stable, and 2.02 (1.41–2.88) for the elevated-increasing trajectory. Similar positive associations were observed for systolic BP trajectories. Compared with those persistently normotensive, participants who developed hypertension had significantly higher SLD risks: 1.62-fold for late-onset and 1.75-fold for both mid-adulthood and early onset. Consistently, a faster rate of BP increase was linked to higher SLD risk.CONCLUSIONS:Long-term BP and hypertension patterns in young adulthood were independently associated with increased midlife SLD risk, with rapidly increasing BP exhibiting the greatest risk. Long-term BP changes may assist in more accurate identification of individuals at higher risk of SLD."}