{"id":"7ac117a0acaf","type":"article","url":"https://hartvaat.nl/2026/03/25/aortacoarctatie-voorspelt-langetermijnmorbiditeit-na-de-arteriele-switchoperatie/","title":"Aortacoarctatie voorspelt langetermijnmorbiditeit na de arteriële-switchoperatie (EPOCH-ASO)","title_en":"Aortic coarctation and long-term morbidity after arterial switch operation: a multicentre international cohort study","category":"algemeen","category_label":"Algemeen","professions":["cardioloog"],"tags":["aortacoarctatie"],"journal":"Heart","doi":"http://heart.bmj.com/cgi/content/short/112/8/437?rss=1","source_url":"https://doi.org/http://heart.bmj.com/cgi/content/short/112/8/437?rss=1","authors":["Ruperti-Repilado","F. J.","Ladron","R.","Lopez-Ayala","P.","Gabra","B.","Gonzalez-Fernandez","V.","Engele","L. J.","Manso","B.","Bouma","B. J.","Gabriel","H.","Schwitz","F.","Possner","M.","Schwerzmann","M.","Rueda","J.","Buendia-Fuentes","F.","Bouchardy","J.","Ladouceur","M.","Dos-Subira","L.","Greutmann","M.","Tobler","D.","Gallego","P."],"significance":5,"published":"2026-03-25","source_date":"2026-03-25","image":"https://hartvaat.nl/global/img/2ea89016db5e.webp","kennis":["https://hartvaat.nl/kennis/antistolling/antistolling-bij-kankerpatienten/","https://hartvaat.nl/kennis/cardiometabool/obstructief-slaapapneu-en-hart/"],"congress":"","summary_en":"After the arterial switch operation (ASO) for transposition of the great arteries, later interventions and complications are common. Whether aortic coarctation (CoA) plays an independent role was unclear. In this international multicentre study (502 adults from the EPOCH-ASO registry, median age 25.5 years), time to first right ventricular outflow tract (RVOT)-related intervention was the primary outcome. Aortic coarctation emerged as the strongest independent predictor of an RVOT intervention. The findings help identify patients after arterial switch at increased risk of later interventions and to follow them more closely.","created":"2026-07-03T10:32:21Z","updated":"2026-07-03T13:31:19Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Na de arteriële-switchoperatie (ASO) voor transpositie van de grote vaten komen latere ingrepen en complicaties vaak voor. Of een aortacoarctatie (CoA) hierin een onafhankelijke rol speelt, was onduidelijk. In deze internationale multicentrische studie (502 volwassenen uit het EPOCH-ASO-register, mediane leeftijd 25,5 jaar) was de tijd tot een eerste ingreep aan de rechterventrikel-uitstroombaan (RVOT) de belangrijkste uitkomst. Een aortacoarctatie bleek de sterkste onafhankelijke voorspeller van een RVOT-ingreep. De bevindingen helpen om patiënten na een arteriële switch met een verhoogd risico op latere ingrepen te identificeren en gerichter te volgen.","abstract_original":"Background\n

In patients with dextro-transposition of the great arteries, cardiovascular interventions and complications are common after the arterial switch operation (ASO). While complex anatomy—typically defined by ventricular septal defects (VSDs)—is often linked to these outcomes, the independent role of aortic coarctation (CoA) remains unclear.

\n\nMethods\n

We analysed 502 adults from the EPOCH (European collaboration for Prospective Outcome research in Congenital Heart disease)-ASO multicentre registry (median age 25.5 years). The primary outcome was time to first right ventricular outflow tract (RVOT)-related intervention. Secondary outcomes included left ventricular outflow tract (LVOT)-related interventions and cardiovascular complications. Associations were assessed using adjusted Cox regression and Andersen-Gill models.

\n\nResults\n

CoA emerged as the strongest independent predictor of RVOT interventio"}