{"id":"46ae7fd030b7","type":"article","url":"https://hartvaat.nl/2026/03/29/uk-biobank-hogere-intensiteit-van-beweging-belangrijker-dan-totale-tijd-voor-car/","title":"UK Biobank: hogere intensiteit van beweging belangrijker dan totale tijd voor cardiovasculair risico","title_en":"","category":"chronische nierziekte","category_label":"Nierziekte","professions":["cardioloog","huisarts","internist"],"tags":["anemie-ckd","biomarkers-cardiovasculair","bloeddrukbehandeling","diabetes-en-hart","diabetes-type-2","farmaco-economie","fidelity","obesitas","ouderen","vrouwen"],"journal":"European heart journal","doi":"10.1093/eurheartj/ehag168","source_url":"https://doi.org/10.1093/eurheartj/ehag168","authors":["Jiehua Wei","Minxue Shen","Shenxin Li","Yi Xiao","Dan Luo","Gerson Ferrari","Dong Hoon Lee","Leandro F M Rezende","Jason M R Gill","Matthew N Ahmadi","Emmanuel Stamatakis","Xiang Chen"],"significance":8,"published":"2026-04-17","source_date":"2026-03-29","image":"","kennis":["https://hartvaat.nl/kennis/cardiometabool/sglt2-remmers-bij-diabetes-hartaandoeningen/","https://hartvaat.nl/kennis/nierziekte/nierziekte-en-cardiovasculair-risico/"],"congress":"","summary_en":"Using wrist-accelerometer data from 96,408 UK Biobank participants, a higher share of vigorous activity (%VPA) showed a non-linear inverse association with MACE, atrial fibrillation, type 2 diabetes, CKD, dementia and all-cause mortality — independent of total activity volume. Participants exceeding 4% VPA had 29–61% lower risk of these outcomes. The study suggests exercise intensity deserves more weight in prevention counselling, alongside the traditional focus on weekly duration.","created":"2026-07-03T10:32:45Z","updated":"2026-07-03T13:31:41Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"In 96.408 deelnemers met accelerometer-data uit de UK Biobank was het aandeel inspannende activiteit (%VPA) omgekeerd geassocieerd met MACE, atriumfibrilleren, diabetes, CKD, dementie en all-cause mortaliteit — onafhankelijk van het totale activiteitsvolume. Deelnemers met meer dan 4% VPA hadden 29–61% lagere kansen op deze aandoeningen. De bevinding nuanceert de klassieke focus op 150 minuten/week matige activiteit: intensiteit toevoegen levert mogelijk meer winst op dan alleen volume. Relevant voor leefstijladvies in de eerstelijnszorg.","abstract_original":"BACKGROUND AND AIMS: While vigorous physical activity (VPA) is known to provide greater health benefits per unit time than moderate activity, the spectrum of these benefits across different chronic diseases and the relative importance of physical activity (PA) intensity vs volume remain unclear. This study examined associations between the proportion of VPA (%VPA) relative to total volume of PA and the incidence of multiple chronic disease outcomes. METHODS: This prospective population-based cohort study included 96,408 participants (mean age 61.9 years, women: 56.3%) with device-measured data (wrist-worn accelerometers) and 375,730 participants (mean age 56.2 years, women: 52.2%) with self-reported PA data (IPAQ) from the UK Biobank. Main outcomes included incidence of eight chronic diseases: major adverse cardiovascular events (MACE), atrial fibrillation (AFib), type 2 diabetes (T2D), immune-mediated inflammatory diseases, metabolic dysfunction-associated steatotic liver disease (MASLD), chronic respiratory diseases (CRD), chronic kidney disease (CKD), and dementia, as well as all-cause mortality. Cox proportional hazards models were used to estimate adjusted hazard ratios and 95% confidence interval. RESULTS: In the device-measured data, non-linear inverse dose-response relationships were observed between %VPA and all outcomes (all P < .001), and these patterns remained consistent across strata of total PA volume. In multivariable models adjusted for total PA volume, participants with >4% VPA had 29%-61% lower risks of these outcomes compared with those with 0% VPA. Joint analyses and population attributable fraction revealed distinct disease-specific patterns: immune-mediated inflammatory diseases showed very strong intensity-dependence with minimal contribution from PA volume (20.3% for intensity vs 1.0% for volume), while MACE (17.8% vs 6.0%), AFib (16.2% vs 5.0%), CRD (21.4% vs 5.6%), and dementia (32.3% vs 8.1%) demonstrated intensity predominance with modest contribution from PA volume, and T2D (26.6% vs 17.7%), MASLD (22.1% vs 16.6%), CKD (23.0% vs 15.3%), and all-cause mortality (31.4% vs 14.2%) showed more balanced contributions from both intensity and volume. CONCLUSIONS: A higher %VPA, independent of total activity volume, is inversely associated with eight major chronic diseases and all-cause mortality. Intensity consistently demonstrated a higher preventive potential than total PA volume. These findings support, whenever possible, prioritizing higher-intensity activities in clinical and public health interventions aimed at preventing non-communicable diseases."}