{"id":"46040","type":"article","url":"https://hartvaat.nl/2026/04/02/aha-verklaring-geavanceerde-karakterisering-van-rechterventrikelfalen/","title":"AHA-verklaring: geavanceerde karakterisering van rechterventrikelfalen","title_en":"Advanced Molecular, Metabolic, and Imaging Approaches to Characterizing Right Ventricular Failure: A Scientific Statement From the American Heart Association","category":"algemeen","category_label":"Algemeen","professions":["cardioloog"],"tags":[],"journal":"Circulation","doi":"https://www.ahajournals.org/doi/abs/10.1161/CIR.0000000000001422","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/CIR.0000000000001422","authors":["Soni Savai Pullamsetti"],"significance":7,"published":"2026-07-16","source_date":"2026-04-02","image":"","kennis":["https://hartvaat.nl/kennis/kleplijden/aortaregurgitatie/","https://hartvaat.nl/kennis/farmacologie/betablokkers-cardiale-indicaties/"],"congress":"","summary_en":"Right ventricular (RV) dysfunction is a major predictor of outcomes in pulmonary hypertension and beyond. This American Heart Association scientific statement describes how chronic pressure overload first drives adaptive RV hypertrophy and then maladaptive remodelling with dilation, fibrosis, stiffness and RV–pulmonary arterial uncoupling, ultimately causing right heart failure. It synthesises advanced molecular, metabolic and imaging approaches to characterising RV failure — relevant not only to (pulmonary arterial) hypertension but also to HFpEF, congenital heart disease and other systemic conditions.","created":"2026-07-03T20:27:09Z","updated":"2026-07-04T19:26:59Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Rechterventrikel(RV)-disfunctie is een belangrijke voorspeller van uitkomsten bij pulmonale hypertensie en daarbuiten. Deze wetenschappelijke verklaring van de American Heart Association beschrijft hoe chronische drukbelasting de RV eerst doet hypertrofiëren (adaptief) en daarna doet ontsporen naar maladaptieve remodellering met dilatatie, fibrose, stijfheid en ontkoppeling van de pulmonale arterie (RV-PA-uncoupling), wat uiteindelijk leidt tot rechterhartfalen. Het document vat geavanceerde moleculaire, metabole en beeldvormende benaderingen samen om RV-falen te karakteriseren — relevant niet alleen voor (pulmonale arteriële) hypertensie, maar ook voor HFpEF, aangeboren hartafwijkingen en andere systemische aandoeningen.","abstract_original":"Right ventricular (RV) dysfunction is a key predictor of outcomes in pulmonary hypertension (PH), substantially contributing to illness and death. As PH progresses, increased pulmonary vascular resistance places chronic pressure overload on the right ventricle. Initially, the right ventricle adapts through hypertrophic remodeling, thickening the heart wall to maintain cardiac output. Over time, this adaptive phase shifts to maladaptive remodeling, marked by RV dilation, fibrosis, stiffness, and decoupling from the pulmonary artery, known as RV–pulmonary arterial uncoupling. This uncoupling reflects the inability of the right ventricle to sustain contractility against elevated afterload, ultimately leading to right heart failure, the primary cause of death in late-stage PH. Awareness of RV dysfunction has grown, extending beyond PH and pulmonary arterial hypertension to systemic conditions, such as heart failure with preserved ejection fraction, congenital heart disease, COVID-19, and c"}