{"id":"46082","type":"article","url":"https://hartvaat.nl/2026/04/10/subklinische-atherosclerose-bij-vrouwen-na-pre-eclampsie-systematische-review-en/","title":"Subklinische atherosclerose bij vrouwen na pre-eclampsie: systematische review en meta-analyse","title_en":"","category":"algemeen","category_label":"Algemeen","professions":["cardioloog","huisarts"],"tags":[],"journal":"Heart","doi":"http://heart.bmj.com/cgi/content/short/112/9/473?rss=1","source_url":"https://doi.org/http://heart.bmj.com/cgi/content/short/112/9/473?rss=1","authors":["Yao","J. V.","Wang","B.","Ganes","A.","Peters","S.","Taylor","A.","Brennecke","S.","Winship","I.","Zentner","D."],"significance":6,"published":"2026-07-22","source_date":"2026-04-10","image":"https://hartvaat.nl/global/img/5e97691e9888.webp","kennis":["https://hartvaat.nl/kennis/cardiometabool/diabetes-type-1-en-hart/","https://hartvaat.nl/kennis/cardiometabool/obesitas-en-hart/"],"congress":"","summary_en":"Women who experienced pre-eclampsia have an increased later-life risk of cardiovascular disease (CVD), but uniform screening recommendations are lacking. Subclinical atherosclerosis offers a window to identify and treat at-risk women, measurable by coronary artery calcium scoring (CAC), carotid intima-media thickness (CIMT) and ankle-brachial index (ABI). This systematic review and meta-analysis (MEDLINE, EMBASE, CINAHL) examined the association between a history of pre-eclampsia and the presence of subclinical atherosclerosis, and how this relates to the timing of measurement. The findings support that prior pre-eclampsia is associated with more subclinical atherosclerosis and underscore the importance of cardiovascular risk evaluation in these women.","created":"2026-07-03T20:27:16Z","updated":"2026-07-04T19:09:44Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Vrouwen die pre-eclampsie doormaakten, hebben later een verhoogd risico op hart- en vaatziekten (HVZ), maar eenduidige aanbevelingen voor screening ontbreken. Subklinische atherosclerose biedt een kans om risicopatiënten vroeg te identificeren en te behandelen, te meten met de coronaire calciumscore (CAC), de intima-media-dikte van de halsslagader (CIMT) en de enkel-armindex (ABI). Deze systematische review en meta-analyse (MEDLINE, EMBASE, CINAHL) onderzocht het verband tussen een voorgeschiedenis van pre-eclampsie en de aanwezigheid van subklinische atherosclerose, en hoe dit samenhangt met het moment van meten. De bevindingen ondersteunen dat een doorgemaakte pre-eclampsie gepaard gaat met meer subklinische atherosclerose en onderstrepen het belang van cardiovasculaire risico-evaluatie bij deze vrouwen.","abstract_original":"Background\n

Women with pre-eclampsia are at increased risk of later-life cardiovascular disease (CVD). Despite suggestions that women affected by pre-eclampsia should undergo routine CVD screening, uniform recommendations are lacking. Subclinical atherosclerosis provides a window of opportunity to identify and treat those at risk of CVD. Coronary artery calcium scoring (CAC), carotid intima–media thickness (CIMT) and ankle brachial index (ABI) are effective methods of detecting subclinical atherosclerosis. This systematic review sought to explore associations between timing of measurement and presence of subclinical atherosclerosis in women with a history of pre-eclampsia.

\n\nMethods\n

We searched the MEDLINE, EMBASE and CINAHL databases for all studies which reported subclinical atherosclerosis in women with a history of pre-eclampsia. Common and random effects models were used to examine the associations between pre-eclampsia and subclinic"}