# Sporten op je eigen bioritme verlaagt de bloeddruk meer: een gerandomiseerde studie

*geplaatst 2026-07-19 · Preventie · Open heart · doi 10.1136/openhrt-2025-003573 · https://hartvaat.nl/2026/04/14/sporten-op-je-eigen-bioritme-verlaagt-de-bloeddruk-meer-een-gerandomiseerde-stud/*

Sluit het tijdstip van bewegen aan op het chronotype ('ochtend-' of 'avondmens'), dan levert dat mogelijk meer cardiometabole winst op. In deze 12 weken durende gerandomiseerde studie (Lahore, Pakistan; 150 zittende volwassenen van 40-60 jaar met minstens één cardiovasculaire risicofactor) werd het chronotype bepaald met een vragenlijst en bevestigd met 48-uurs lichaamstemperatuurmeting. Deelnemers trainden begeleid (5×/week, 40 min matige intensiteit) óf op hun voorkeurstijdstip (chronotype-aligned, CAE) óf juist op hun niet-voorkeurstijdstip (CME). De CAE-groep verbeterde significant sterker op de systolische bloeddruk (-10,8 vs. -5,5 mmHg), de diastolische bloeddruk, de hartslagvariabiliteit (RMSSD), de piek-VO2, het LDL, de nuchtere glucose en de slaapkwaliteit (PSQI). Bewegen afstemmen op het individuele bioritme zou dus een goedkope, gepersonaliseerde manier kunnen zijn om de cardiovasculaire gezondheid te verbeteren.

## English: Chronotype-aligned exercise timing in middle-aged adults at cardiometabolic risk: a randomised controlled trial.

Aligning the timing of exercise with chronotype ('morning' or 'evening' type) may yield greater cardiometabolic benefit. In this 12-week randomised trial (Lahore, Pakistan; 150 sedentary adults aged 40-60 with at least one cardiovascular risk factor), chronotype was determined by questionnaire and confirmed with 48-hour core body-temperature monitoring. Participants trained supervised (5×/week, 40 min moderate intensity) either at their preferred time (chronotype-aligned, CAE) or at their non-preferred time (CME). The CAE group improved significantly more in systolic blood pressure (-10.8 vs -5.5 mmHg), diastolic blood pressure, heart-rate variability (RMSSD), peak VO2, LDL, fasting glucose and sleep quality (PSQI). Matching exercise to individual chronotype could thus be a low-cost, personalised way to improve cardiovascular health.

## Abstract (original, from the publication)

OBJECTIVE: To investigate whether aligning exercise timing with chronotype enhances cardiometabolic and sleep-related benefits in sedentary adults with cardiovascular risk factors. METHODS: In this 12-week randomised controlled trial conducted in Lahore, Pakistan (January-June 2025), 150 sedentary adults (aged 40-60) with at least one cardiovascular risk factor were recruited and categorised as morning-type or evening-type using the Morningness-Eveningness Questionnaire and validated by 48 hour core body temperature monitoring. Participants were randomised into a chronotype-aligned exercise (CAE) group exercising at their preferred time, or a chronotype-misaligned exercise (CME) group exercising at their non-preferred time. Moderate-intensity aerobic training (5 sessions/week, 40 min/session) was supervised. Primary outcomes included systolic and diastolic blood pressure (BP) and heart rate variability (RMSSD); secondary outcomes included peak oxygen consumption (VO₂ peak), low density lipoprotein (LDL), fasting glucose and sleep quality (PSQI), assessed pre- and post-intervention. RESULTS: Of 150 randomised participants, 134 completed the study (CAE: n=64; CME: n=70). CAE led to significantly greater improvements in systolic BP (-10.8 vs -5.5 mm Hg, p=0.002), diastolic BP, RMSSD, VO₂ peak, LDL, fasting glucose and PSQI scores compared with CME. Repeated measures analysis of variance (ANOVA) revealed significant group×time interactions across all outcomes (eg, systolic BP: η²=0.095, p=0.005). The reduction in systolic BP in the CAE group was substantial and significantly greater than in the CME group. CONCLUSION: Aligning exercise timing with individual chronotype significantly enhances cardiometabolic and sleep-related outcomes in at-risk adults. Chronotype-based exercise prescriptions may offer a cost-effective, personalised approach to improving cardiovascular health.

Auteurs: Arsalan Tariq, Mohammed Harris Khalid, Muhammad Ammar

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Bron: Open heart, https://doi.org/10.1136/openhrt-2025-003573. Bijgewerkt 2026-07-04T19:26:56Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.