{"id":"46024","type":"article","url":"https://hartvaat.nl/2026/04/16/winteropname-voor-acuut-hartfalen-gaat-gepaard-met-hogere-sterfte/","title":"Winteropname voor acuut hartfalen gaat gepaard met hogere sterfte","title_en":"Clinical Impact of Seasonal and Environmental Factors in Patients with Acute Heart Failure.","category":"chronische nierziekte","category_label":"Nierziekte","professions":["cardioloog","internist"],"tags":[],"journal":"European heart journal. Acute cardiovascular care","doi":"10.1093/ehjacc/zuag059","source_url":"https://doi.org/10.1093/ehjacc/zuag059","authors":["Akito Okabe","Akiomi Yoshihisa","Yu Sato","Naoto Ohashi","Satoshi Okochi","Toranosuke Sekine","Ryo Ogawara","Yukiko Sugawara","Akihiko Sato","Shunsuke Miura","Tetsuro Yokokawa","Takeshi Shimizu","Tomofumi Misaka","Takamasa Sato","Takashi Kaneshiro","Masayoshi Oikawa","Atsushi Kobayashi","Kazuhiko Nakazato","Yasuchika Takeishi"],"significance":6,"published":"2026-07-14","source_date":"2026-04-16","image":"","kennis":["https://hartvaat.nl/kennis/farmacologie/betablokkers-cardiale-indicaties/"],"congress":"","summary_en":"In a cohort of 2,857 patients hospitalised for heart failure, seasonal and environmental factors were examined. The winter group was older, had more comorbidity and higher in-hospital and 90-day mortality than the autumn group (odds ratios 1.7–2.1). Lower temperature was associated with 90-day mortality, shorter sunshine duration with all-cause mortality, and higher PM2.5 with in-hospital cardiac mortality; atmospheric pressure, humidity and influenza activity were not. The findings suggest a role for cold and limited sunlight in winter heart-failure mortality.","created":"2026-07-03T20:27:07Z","updated":"2026-07-04T19:27:01Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"In een cohort van 2.857 patiënten die werden opgenomen voor hartfalen werden seizoens- en omgevingsfactoren onderzocht. De wintergroep was ouder, had meer comorbiditeit en een hogere ziekenhuis- en 90-dagensterfte dan de herfstgroep (odds ratio's 1,7–2,1). Een lagere temperatuur hing samen met 90-dagensterfte, een kortere zonduur met totale sterfte en hogere PM2,5-concentraties met cardiale ziekenhuissterfte; luchtdruk, luchtvochtigheid en griepactiviteit niet. De bevindingen wijzen op een rol van koude en weinig zonlicht bij de wintergebonden hartfalensterfte.","abstract_original":"BACKGROUND: Seasonal factors, particularly during winter, have been associated with worsened heart failure (HF). However, seasonal differences in clinical characteristics, clinical outcomes and environmental mechanisms remain unclear. METHODS: We analyzed 2,857 patients hospitalized for HF. Patients were classified into four groups by season of admission: spring (March to May, n=788, 27.6%), summer (June to August, n= 699, 24.5%), fall (September to November, n=645, 22.6%) and winter (December to February, n =725, 25.4%). Baseline characteristics, clinical outcomes and environmental factors corresponding to the admission month-such as temperature, atmospheric pressure, relative humidity, sunshine duration, influenza activity and PM2.5 concentration-were compared among the groups. RESULTS: The winter group was older and more frequently had hypertension, diabetes, chronic kidney disease and thyroid disease. No seasonal differences were observed in sex, body mass index, HF etiology, other comorbidities, B-type natriuretic peptide levels, or left ventricular ejection fraction. Compared with the fall group, the winter group was associated with higher risk of in-hospital cardiac and all-cause mortality, 90-day cardiac and all-cause mortality (odds ratio 2.13, 1.85, 1.69, 2.01, 1.80, respectively, p<0.05). With respect to environmental factors, (1) lower temperature was associated with 90-day cardiac and all-cause mortality; (2) shorter sunshine duration was associated with 90-day all-cause mortality; and (3) higher PM2.5 concentrations were associated with in-hospital cardiac mortality. In contrast, atmospheric pressure, relative humidity, and influenza activity were not associated with clinical outcomes. CONCLUSIONS: Winter admission for HF was associated with older age, more comorbidities and higher in-hospital and short-term mortality, which may be partly explained by lower temperatures and shorter sunlight."}