{"id":"46044","type":"article","url":"https://hartvaat.nl/2026/04/17/lagere-kaliuminname-hangt-samen-met-meer-hart-en-vaatziekte-bij-ckd-vooral-bij-v/","title":"Lagere kaliuminname hangt samen met meer hart- en vaatziekte bij CKD — vooral bij vrouwen","title_en":"Sex-Specific Cardiovascular Risk of Lower Potassium Intake in Patients with CKD.","category":"chronische nierziekte","category_label":"Nierziekte","professions":["cardioloog","huisarts","internist"],"tags":[],"journal":"European journal of preventive cardiology","doi":"10.1093/eurjpc/zwag226","source_url":"https://doi.org/10.1093/eurjpc/zwag226","authors":["Tatsuya Suenaga","Shigeru Tanaka","Hiromasa Kitamura","Kazuhiro Okamura","Shunsuke Yamada","Kazuhiko Tsuruya","Toshiaki Nakano","Tetsuro Ago"],"significance":6,"published":"2026-07-17","source_date":"2026-04-17","image":"","kennis":["https://hartvaat.nl/kennis/nierziekte/nierziekte-en-cardiovasculair-risico/","https://hartvaat.nl/kennis/cardiometabool/diabetes-type-1-en-hart/"],"congress":"","summary_en":"Lower potassium intake is associated with more cardiovascular disease (CVD) in the general population, with sex differences. In this Japanese prospective study (Fukuoka Kidney Disease Registry; 4,314 patients with chronic kidney disease, 5-year follow-up), estimated potassium intake (from spot urine) was related to cardiovascular events. Over five years, 431 patients had an event. There was a significant interaction with sex (p<0.001): in women, lower potassium intake was strongly associated with more events (HR 2.97), but not in men (HR 0.98). In CKD, low potassium intake thus appears to be a risk particularly in women — though potassium management in CKD requires caution because of hyperkalaemia risk.","created":"2026-07-03T20:27:09Z","updated":"2026-07-04T19:26:58Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Een lagere kaliuminname is in de algemene bevolking geassocieerd met meer hart- en vaatziekte, met sekseverschillen. In deze Japanse prospectieve studie (Fukuoka Kidney Disease Registry; 4.314 patiënten met chronische nierschade, vijf jaar follow-up) werd de geschatte kaliuminname (uit spoturine) gerelateerd aan cardiovasculaire events. Over vijf jaar kregen 431 patiënten een event. Er was een significante interactie met geslacht (p<0,001): bij vrouwen was een lagere kaliuminname sterk geassocieerd met meer events (HR 2,97), bij mannen niet (HR 0,98). Bij CKD lijkt een lage kaliuminname dus vooral bij vrouwen een risico — al vraagt het kaliumbeleid bij CKD om voorzichtigheid vanwege het hyperkaliëmierisico.","abstract_original":"BACKGROUND: Lower potassium intake is associated with an increased risk of cardiovascular disease (CVD) in the general population, with observed sex differences. However, few studies have investigated the relationship between potassium intake and CVD in patients with chronic kidney disease (CKD), and sex-specific differences have not been well examined. METHODS: A total of 4,314 patients aged 18 years or older in Japan were prospectively followed for 5 years using data from the Fukuoka Kidney disease Registry study. The patients were divided into sex-specific quartiles according to the estimated potassium intake, which was calculated using the Tanaka formula from spot urine samples. The primary outcome was the occurrence of CVD events. Cox proportional hazards models were used to evaluate the association between the estimated potassium intake and CVD in the overall cohort with stratification by sex. RESULTS: Over a 5-year follow-up, 431 patients developed CVD (292 [12.1%] men and 139 [7.3%] women). In the overall cohort, patients in the lowest quartile of estimated potassium intake tended to have a higher hazard ratio (HR) for CVD than those in the highest quartile (HR [95% CI], 1.41 [0.97-2.03]). A significant interaction between sex and potassium intake was observed (p<0.001). In sex-stratified analyses, lower potassium intake was significantly associated with an increased risk of CVD in women (HR [95% CI]: men, 0.98 [0.63-1.53]; women, 2.97 [1.44-6.10]). CONCLUSIONS: Lower estimated potassium intake is associated with a higher risk of CVD in patients with CKD, with a particularly strong association in women."}