{"id":"f6a6ed5d8bf1","type":"article","url":"https://hartvaat.nl/2026/04/24/astma-geassocieerd-met-verhoogd-risico-op-degeneratieve-hartklepziekte-uk-bioban/","title":"Astma geassocieerd met verhoogd risico op degeneratieve hartklepziekte — UK Biobank","title_en":"","category":"algemeen","category_label":"Algemeen","professions":["cardioloog","huisarts"],"tags":["abelacimab","acuut-hartfalen","biomarkers-cardiovasculair","bloeddrukbehandeling","diabetes-type-2","dyslipidemie","farmaco-economie","gepersonaliseerde-geneeskunde","laminopathie","menopauze","ouderen","primaire-preventie","statines","vrouwen"],"journal":"Heart","doi":"http://heart.bmj.com/cgi/content/short/112/10/576?rss=1","source_url":"https://doi.org/http://heart.bmj.com/cgi/content/short/112/10/576?rss=1","authors":["Wang","Z.","Qian","X.","Lv","J.","Li","Z.","Yin","Z.","Wang","C.","Zhao","S.","Gao","X.","Wu","Y."],"significance":5,"published":"2026-05-11","source_date":"2026-04-24","image":"https://hartvaat.nl/global/img/54665943e7e6.webp","kennis":["https://hartvaat.nl/kennis/cardiometabool/diabetes-en-cardiovasculair-risico/","https://hartvaat.nl/kennis/cardiometabool/diabetes-type-1-en-hart/"],"congress":"","summary_en":"A prospective cohort analysis of 483,735 UK Biobank participants (median age 56.5 years, 45.2% male) free of valvular heart disease at baseline. Cox regression adjusted for demographic, lifestyle and clinical covariates. The study assessed incidence of aortic stenosis, aortic regurgitation, mitral regurgitation and pulmonary regurgitation. Asthma was associated with higher risk across several degenerative valve disorders, with sensitivity analyses for asthma medications and duration. An under-recognised cardiovascular dimension of asthma that warrants further study.","created":"2026-07-03T10:32:54Z","updated":"2026-07-03T13:31:49Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Prospectieve cohortanalyse van 483.735 UK Biobank-deelnemers (mediane leeftijd 56,5 jaar, 45,2% man) zonder hartklepziekte bij baseline. Cox-regressie corrigeerde voor demografische, leefstijl- en klinische covariaten. De studie evalueerde incidentie van aortastenose, aorta-insufficiëntie, mitralisinsufficiëntie en pulmonale insufficiëntie. Astma bleek geassocieerd met verhoogd risico op meerdere degeneratieve klepafwijkingen, met sensitiviteitsanalyses voor astma-medicatie en duur. Een onderbelichte cardiovasculaire dimensie van astma die aanvullend onderzoek vraagt.","abstract_original":"Background\n

Asthma has been associated with the development and progression of various cardiovascular diseases but its relationship with degenerative valvular heart disease (VHD) remains unclear. This study investigated the association between asthma and incident degenerative VHD, including aortic stenosis (AS), aortic regurgitation (AR), mitral regurgitation (MR) and pulmonary regurgitation (PR).

\n\nMethods\n

We analysed 483 735 participants from the UK Biobank (median age 56.5 years; 45.2% male) who were free of VHD at baseline. Asthma status was self-reported at recruitment. Incident VHD was ascertained through hospital admission and mortality records using International Classification of Diseases, Tenth Revision codes. Cox proportional hazards models were used to estimate HRs and 95% CIs for each VHD subtype, adjusting for demographic, lifestyle and clinical covariates. Sensitivity analyses accounted for asthma medications, duration of asthma "}