{"id":"0e0a19e311ae","type":"article","url":"https://hartvaat.nl/2026/04/24/bayesiaanse-netwerkmeta-analyse-vergelijkt-revascularisatie-bij-stabiele-ischemi/","title":"Bayesiaanse netwerkmeta-analyse vergelijkt revascularisatie bij stabiele ischemische hartziekte","title_en":"","category":"algemeen","category_label":"Algemeen","professions":["cardioloog"],"tags":[],"journal":"Heart","doi":"http://heart.bmj.com/cgi/content/short/112/10/530?rss=1","source_url":"https://doi.org/http://heart.bmj.com/cgi/content/short/112/10/530?rss=1","authors":["Kawczynski","M. J.","Barili","F.","Brophy","J. M.","De Caterina","R.","Biondi Zoccai","G.","Anselmi","A.","Boden","W. E.","Parolari","A.","Heuts","S.","on behalf of the INTEGRITTY initiative","Albuquerque","Almeida","Anselmi","Almeida","Anselmi","Beurtheret","Biondi-Zoccai","Boden","Borger","Brophy","Buttiglione","Dayan","Caterina","Cuesta","Firstenberg","Garcia-Villareal","Gomes","Heuts","Kaul","Kawczynski","Mandrola","Cuartas","Misfield","Musumeci","Parolari","Quintana","Redberg","Riad","Stuart","Ronco","Uva","Tomasi","Verhoye","Zenati","Dib"],"significance":7,"published":"2026-05-10","source_date":"2026-04-24","image":"https://hartvaat.nl/global/img/54665943e7e6.webp","kennis":["https://hartvaat.nl/kennis/coronairlijden/stemi/","https://hartvaat.nl/kennis/coronairlijden/esc-richtlijn-chronisch-coronairlijden-2024/"],"congress":"","summary_en":"A hierarchical Bayesian network meta-analysis (PROSPERO CRD42024541215) of RCTs published 2005-June 2025 compared three initial strategies for non-acute myocardial ischaemic syndromes: optimal medical therapy alone, PCI added to OMT and CABG added to OMT. The primary outcome was long-term all-cause mortality. The analysis quantifies the strength of evidence on the comparative effectiveness of revascularisation — an area where current ESC and ACC/AHA guidelines diverge — and provides a quantitative framework for decisions in stable coronary disease.","created":"2026-07-03T10:32:52Z","updated":"2026-07-03T13:31:48Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Hierarchische Bayesiaanse netwerkmeta-analyse (PROSPERO CRD42024541215) van RCT's tussen 2005 en juni 2025 vergelijkt drie startstrategieën bij niet-acute ischemische hartziekte: optimale medische therapie, PCI bovenop OMT en CABG bovenop OMT. Het primaire eindpunt was lange-termijn all-cause mortaliteit. De analyse weegt de sterkte van het bewijs voor de comparatieve effectiviteit van revascularisatie — een onderwerp waarop de huidige ESC- en ACC/AHA-richtlijnen op dit moment uiteenlopen. De resultaten geven een gekwantificeerd kader voor klinische besluitvorming bij stabiele coronairlijden.","abstract_original":"Background\n

Contemporary guidelines by the European Society for Cardiology and American College of Cardiology/American Heart Association for the treatment of non-acute myocardial ischaemic syndromes dispute the value of revascularisation and differ in their recommendation to perform revascularisation. A Bayesian network meta-analysis was performed, evaluating the strength of evidence for the comparative incremental effectiveness of coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI) over medical therapy on long-term outcomes.

\n\nMethods\n

A hierarchical Bayesian network meta-analysis was designed (PROSPERO CRD42024541215, date 20 May 2024), including randomised controlled trials (RCTs) published between 2005 and 10 June 2025, which consisted of three initial treatment modalities: optimal medical therapy (OMT), PCI+OMT and CABG+OMT. The primary outcome was all-cause mortality at maximum follow-up; secondary outcom"}