{"id":"9d1ed8193d47","type":"article","url":"https://hartvaat.nl/2026/04/24/cardiovasculaire-ziekte-bij-sikkelcelziekte-ondergediagnosticeerde-drijver-van-m/","title":"Cardiovasculaire ziekte bij sikkelcelziekte: ondergediagnosticeerde drijver van mortaliteit","title_en":"","category":"algemeen","category_label":"Algemeen","professions":["cardioloog","internist"],"tags":["acuut-hartfalen","atleten","biomarkers-cardiovasculair","bloeddrukbehandeling","bradycardie","cardiogene-shock","cardiomyopathie-gerichte-therapie","cardiovasculaire-genetica","diabetes-en-hart","diabetes-type-2","echocardiografie","farmaco-economie","fractional-flow-reserve","gedilateerde-cardiomyopathie","gepersonaliseerde-geneeskunde","hartkatheterisatie","hypertrofische-cardiomyopathie","laminopathie","myocardinfarct","obesitas","ouderen","plotse-hartdood","richtlijnen-esc","secundaire-preventie","slaapapneu","ventrikelfibrilleren","vrouwen"],"journal":"Heart","doi":"http://heart.bmj.com/cgi/content/short/112/10/539?rss=1","source_url":"https://doi.org/http://heart.bmj.com/cgi/content/short/112/10/539?rss=1","authors":["Haroun","E.","Agrawal","A.","Arockiam","A. D.","El Dahdah","J.","Kassab","J.","Nakhla","M.","Chedid El Helou","M.","Sanaka","H.","Zalaquett","Z.","Kaur","S.","Dong","T.","Hanna","R.","Griffin","B.","Wang","T. K. M."],"significance":6,"published":"2026-05-11","source_date":"2026-04-24","image":"https://hartvaat.nl/global/img/54665943e7e6.webp","kennis":["https://hartvaat.nl/kennis/cardiometabool/diabetes-en-cardiovasculair-risico/","https://hartvaat.nl/kennis/cardiometabool/obesitas-en-hart/"],"congress":"","summary_en":"A contemporary review of cardiovascular complications in sickle cell disease: myocardial dysfunction, pulmonary hypertension, cardiac iron overload, arrhythmias, myocardial infarction, stroke and sudden death. They remain under-recognised despite their growing role in morbidity and premature mortality. Cardiac MRI with T2* mapping and ECV sequences, speckle-tracking echocardiography and invasive exercise testing reveal a distinct phenotype of restrictive cardiomyopathy with high-output heart failure. The review provides SCD-specific risk stratification and treatment algorithms.","created":"2026-07-03T10:32:54Z","updated":"2026-07-03T18:39:32Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Hedendaagse review over cardiovasculaire complicaties bij sikkelcelziekte: myocarddisfunctie, pulmonale hypertensie, cardiale ijzerstapeling, ritmestoornissen, myocardinfarct, beroerte en plotse dood. Ze blijven onderherkend ondanks toenemende impact op morbiditeit en vroege mortaliteit. Cardiale MR met T2*-mapping en ECV-sequenties, speckle-tracking-echo en invasief inspanningsonderzoek leggen een uniek fenotype bloot van restrictieve cardiomyopathie met high-output hartfalen. De review presenteert risicostratificatie- en behandelalgoritmes specifiek voor sikkelcelziekte.","abstract_original":"<p>Cardiovascular complications are increasingly recognised as a major driver of morbidity and early mortality in patients with sickle cell disease (SCD), yet they remain underdiagnosed and underappreciated. This contemporary review synthesises current knowledge across a spectrum of cardiovascular manifestations&mdash;including myocardial dysfunction, pulmonary hypertension, cardiac iron overload, arrhythmias, myocardial infarction, stroke and sudden death&mdash;with emphasis on their unique pathophysiological mechanisms in SCD. We highlight emerging diagnostic tools such as cardiac magnetic resonance with T2* mapping and extracellular volume sequences, speckle-tracking echocardiography and invasive exercise testing, which can revealing a distinct phenotype combining restrictive cardiomyopathy and high-output heart failure. Practical algorithms for risk stratification and disease monitoring are presented alongside evidence-based and SCD-specific management approaches, including the rol"}