# Cardiovasculaire ziekte bij sikkelcelziekte: ondergediagnosticeerde drijver van mortaliteit *geplaatst 2026-05-11 · Algemeen · Heart · doi http://heart.bmj.com/cgi/content/short/112/10/539?rss=1 · https://hartvaat.nl/2026/04/24/cardiovasculaire-ziekte-bij-sikkelcelziekte-ondergediagnosticeerde-drijver-van-m/* Hedendaagse review over cardiovasculaire complicaties bij sikkelcelziekte: myocarddisfunctie, pulmonale hypertensie, cardiale ijzerstapeling, ritmestoornissen, myocardinfarct, beroerte en plotse dood. Ze blijven onderherkend ondanks toenemende impact op morbiditeit en vroege mortaliteit. Cardiale MR met T2*-mapping en ECV-sequenties, speckle-tracking-echo en invasief inspanningsonderzoek leggen een uniek fenotype bloot van restrictieve cardiomyopathie met high-output hartfalen. De review presenteert risicostratificatie- en behandelalgoritmes specifiek voor sikkelcelziekte. ## English: A contemporary review of cardiovascular complications in sickle cell disease: myocardial dysfunction, pulmonary hypertension, cardiac iron overload, arrhythmias, myocardial infarction, stroke and sudden death. They remain under-recognised despite their growing role in morbidity and premature mortality. Cardiac MRI with T2* mapping and ECV sequences, speckle-tracking echocardiography and invasive exercise testing reveal a distinct phenotype of restrictive cardiomyopathy with high-output heart failure. The review provides SCD-specific risk stratification and treatment algorithms. ## Abstract (original, from the publication)

Cardiovascular complications are increasingly recognised as a major driver of morbidity and early mortality in patients with sickle cell disease (SCD), yet they remain underdiagnosed and underappreciated. This contemporary review synthesises current knowledge across a spectrum of cardiovascular manifestations—including myocardial dysfunction, pulmonary hypertension, cardiac iron overload, arrhythmias, myocardial infarction, stroke and sudden death—with emphasis on their unique pathophysiological mechanisms in SCD. We highlight emerging diagnostic tools such as cardiac magnetic resonance with T2* mapping and extracellular volume sequences, speckle-tracking echocardiography and invasive exercise testing, which can revealing a distinct phenotype combining restrictive cardiomyopathy and high-output heart failure. Practical algorithms for risk stratification and disease monitoring are presented alongside evidence-based and SCD-specific management approaches, including the rol Auteurs: Haroun, E., Agrawal, A., Arockiam, A. D., El Dahdah, J., Kassab, J., Nakhla, M., Chedid El Helou, M., Sanaka, H., Zalaquett, Z., Kaur, S., Dong, T., Hanna, R., Griffin, B., Wang, T. K. M. --- Bron: Heart, https://doi.org/http://heart.bmj.com/cgi/content/short/112/10/539?rss=1. Bijgewerkt 2026-07-03T18:39:32Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.