{"id":"1b55802246ba","type":"article","url":"https://hartvaat.nl/2026/04/24/crt-bij-volwassenen-met-systemische-rechterventrikel-gemengde-uitkomsten-in-inte/","title":"CRT bij volwassenen met systemische rechterventrikel: gemengde uitkomsten in internationaal cohort","title_en":"","category":"algemeen","category_label":"Algemeen","professions":["cardioloog"],"tags":["cardiale-resynchronisatie","vrouwen"],"journal":"Heart","doi":"http://heart.bmj.com/cgi/content/short/112/10/549?rss=1","source_url":"https://doi.org/http://heart.bmj.com/cgi/content/short/112/10/549?rss=1","authors":["Fusco","F.","Scognamiglio","G.","Dellborg","M.","Dehghani","P.","Jameson","S. M.","Kay","W. A.","Cramer","J. W.","Vonder Muhll","I.","Krieger","E. V.","Rodriguez","F. H.","Burchill","L. J.","Nicolarsen","J.","Kay","J.","Kauling","R. M.","Shah","S.","Magalski","A.","Wong","J.","Celermajer","D. S.","Baker","D. W.","Roos-Hesselink","J. W.","Ginde","S.","Aboulhosn","J.","Kuo","M.","DeZorzi","C.","Khairy","P.","Rodriguez-Monserrate","C. P.","Kutty","S.","Wilson","W.","Lubert","A. M.","Grewal","J.","Han","F.","Cotts","T.","Pylypchuk","S.","Gupta","T.","Antonova","P.","ODonnell","C.","John","A.","Gallego","P.","van Dissel","A.","Opotowsky","A. R.","Yeung","E.","Broberg","C. S.","Sarubbi","B."],"significance":5,"published":"2026-05-09","source_date":"2026-04-24","image":"https://hartvaat.nl/global/img/54665943e7e6.webp","kennis":["https://hartvaat.nl/kennis/ritmestoornissen/bundeltakblok/","https://hartvaat.nl/kennis/coronairlijden/stemi/"],"congress":"","summary_en":"An international retrospective study (33 centres) of 1,721 adults with a systemic right ventricle — after atrial switch for transposition of the great arteries or with congenitally corrected TGA — of whom 105 (3.5%) underwent cardiac resynchronisation therapy. With a median 4.6-year follow-up, the primary endpoint was overall and heart-failure-free survival. CRT in this unique congenital population shows heterogeneous effects depending on baseline QRS width and function; careful selection remains essential for clinical gain.","created":"2026-07-03T10:32:52Z","updated":"2026-07-03T13:31:48Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Internationaal retrospectief onderzoek (33 centra) bij 1.721 volwassenen met systemische rechterventrikel — na atriumswitch voor TGA of bij congenitaal gecorrigeerde TGA — onder wie 105 (3,5%) cardiale resynchronisatietherapie ondergingen. Mediane follow-up was 4,6 jaar. Het primaire eindpunt was overleving en hartfalenvrije overleving. CRT in deze unieke congenitale populatie laat heterogene effecten zien afhankelijk van QRS-breedte en functionele baseline; selectie blijft cruciaal voor klinische winst.","abstract_original":"Background\n

Cardiac resynchronisation therapy (CRT) is a key treatment for heart failure (HF) in acquired heart disease, but its benefits in adults with congenital heart disease and a systemic right ventricle (sRV) remain unclear. This study aimed to assess whether CRT improves outcomes in patients with sRV.

\n\nMethods\n

This is an international, retrospective study including patients >18 years from 33 centres with transposition of the great arteries (TGA) following atrial switch operation and congenitally corrected TGA. The primary endpoint included overall survival and survival free from HF. The secondary endpoint was a composite of death, hospitalisation for HF, heart transplant, mechanical support and ventricular tachycardia/implantable cardioverter-defibrillator therapies.

\n\nResults\n

We identified 105 out of 1721 patients (3.5%) who underwent CRT. Median follow-up after CRT implant was 4.6 (1.6–8) years. QRS "}