{"id":"d77503e4ac37","type":"article","url":"https://hartvaat.nl/2026/04/27/genen-voor-bloeddruk-in-de-kindertijd-voorspellen-cardiometabool-risico-op-later/","title":"Genen voor bloeddruk in de kindertijd voorspellen cardiometabool risico op latere leeftijd","title_en":"","category":"algemeen","category_label":"Algemeen","professions":["cardioloog","huisarts"],"tags":["abelacimab","acuut-hartfalen","alcoholgebruik","bloeddrukbehandeling","cardiovasculaire-genetica","diabetes-en-hart","diabetes-type-1","diabetes-type-2","dyslipidemie","ezetimibe","familiaire-hypercholesterolemie","familiaire-hypercholesterolemie-screening","farmaco-economie","gepersonaliseerde-geneeskunde","laminopathie","menopauze","obesitas","ouderen","primaire-preventie","statines","vrouwen"],"journal":"European heart journal","doi":"10.1093/eurheartj/ehag313","source_url":"https://doi.org/10.1093/eurheartj/ehag313","authors":["Tian Xie","Alireza Ani","Ahmad Vaez","Ilja M Nolte","Shaoyong Su","Mami Ishikuro","Siqi Wang","Wenbo Zhang","Ana Goncalves Soares","Ehsan Motazedi","Lucinda Calas","Justiina Ronkainen","Casper-Emil T Pedersen","Xueling Lu","Sara E Stinson","Janine F Felix","Evelina Stankevic","Carol A Wang","Elisabeth Thiering","Dietmar Fernández","Beatriz Calvo-Serra","Maria G Stathopoulou","Ruby Fore","Ashish Kumar","Johanna Tuhkanen","Jose Ramon Bilbao","Jesus Ibarluzea","Aaron Isaacs","Cilius Esmann Fonvig","Fernando Rivadeneira","Morten Asp Vonsild Lund","Louise Aas Holm","Peter J van der Most","Harriëtte Riese","Akira Narita","Gen Tamiya","Claudia Flexeder","Rikstje Wiersma","Anna D Argoty-Pantoja","Rebecca Vinding","Tine Willum Hansen","Thomas Kümler","Marisa Estarlich","Mariona Bustamante","Wen Lun Yuan","Anne Boland-Augé","Jean-François Deleuze","Alexandros M Petrelis","Sheryl Rifas-Shiman","Eero Kajantie","Nora Fernandez-Jimenez","Loreto Santa-Marina","Ilja C W Arts","Jari Lahti","Timo Strandberg","Inger Kull","Anna Bergström","Marie-France Hivert","Klaus Bønnelykke","Shinichi Kuriyama","Lawrence J Beilin","Trevor A Mori","Catharina A Hartman","Niels Grarup","Carel Thijs","Katri Räikkönen","Erik Melén","Emily Oken","Sophie Visvikis-Siest","Kristine B Gützkow","Regina Grazuleviciene","Barbara Heude","Leda Chatzi","Martine Vrijheid","Marie Standl","Tanja Vrijkotte","Craig E Pennell","Albertine J Oldehinkel","Torben Hansen","Vincent W V Jaddoe","Jens-Christian Holm","Sylvain Sebert","Nicholas J Timpson","Taku Obara","Xiaoling Wang","Deborah A Lawlor","Eva Corpeleijn","Tarunveer S Ahluwalia","Harold Snieder"],"significance":7,"published":"2026-05-09","source_date":"2026-04-27","image":"","kennis":["https://hartvaat.nl/kennis/coronairlijden/ranolazine-bij-angina/","https://hartvaat.nl/kennis/cardiometabool/diabetes-en-cardiovasculair-risico/"],"congress":"","summary_en":"The largest paediatric GWAS meta-analysis to date (28,425 children for BP, 22,565 for heart rate, ages 4-17) identified eight genome-wide significant loci for childhood blood pressure and three for heart rate — all novel in children but previously reported in adults. Childhood polygenic risk scores explained up to 1.6% of BP and 5.2% of HR variance. In the UK Biobank, higher childhood-BP PRS levels were significantly associated with adult hypertension, angina, myocardial infarction and cardiovascular mortality — supporting cardiovascular prevention strategies that begin early in life.","created":"2026-07-03T10:32:52Z","updated":"2026-07-03T18:39:31Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"De grootste pediatrische GWAS-meta-analyse tot dusver (28.425 kinderen voor bloeddruk, 22.565 voor hartfrequentie, 4-17 jaar) identificeerde acht genoombrede loci voor kinderbloeddruk en drie loci voor hartfrequentie — alle nieuw bij kinderen, eerder gezien bij volwassenen. Polygene risicoscores op kinderleeftijd verklaarden tot 1,6% van de BP- en 5,2% van de HF-variantie. In de UK Biobank waren hogere kinder-BP-PRS-niveaus geassocieerd met hypertensie, angina, myocardinfarct en cardiovasculaire mortaliteit op volwassen leeftijd. De resultaten ondersteunen vroegtijdige cardiovasculaire preventie.","abstract_original":"BACKGROUND AND AIMS: To elucidate the genetic architecture of blood pressure (BP) and heart rate (HR) during early life and assess their potential relevance to adult health outcomes. METHODS: The largest genome-wide association study (GWAS) meta-analyses to date of childhood systolic BP, diastolic BP, pulse pressure, and mean arterial pressure (n = 28 425) and HR (n = 22 565) were conducted in children of European ancestry aged 4-17 years. Follow-up analyses included comparisons with adult GWAS results, polygenic risk score (PRS) analyses in independent cohorts of diverse ancestries, and a phenome-wide association study in the UK Biobank. RESULTS: Eight genome-wide significant loci were identified for childhood BP (KIAA2013, CACNB2, PLCE1, PAX2, COL4A2, RP11-236L14.1, CFDP1, TPX2) and three loci for childhood HR (CCDC141, ACHE, MYH6); all novel in children but previously reported in adults. Childhood PRSs explained up to 1.6% of BP variance and 5.2% of HR variance among children of European ancestry. Genetic correlations between childhood and adulthood BP traits were moderate (rg = 0.4-0.7), suggesting age-specific genetic effects on BP. In the UK Biobank, higher childhood BP PRS levels were significantly associated with a broad range of adult health outcomes, particularly cardiometabolic outcomes such as hypertension, angina, myocardial infarction, and cardiovascular disease-related mortality. CONCLUSIONS: These findings advance the understanding of the genetic architecture of childhood BP and HR and provide compelling genetic evidence linking childhood BP to a broad spectrum of adult health outcomes-particularly cardiometabolic conditions-which may inform targeted prevention strategies from a young age."}