# Genen voor bloeddruk in de kindertijd voorspellen cardiometabool risico op latere leeftijd

*geplaatst 2026-05-09 · Algemeen · European heart journal · doi 10.1093/eurheartj/ehag313 · https://hartvaat.nl/2026/04/27/genen-voor-bloeddruk-in-de-kindertijd-voorspellen-cardiometabool-risico-op-later/*

De grootste pediatrische GWAS-meta-analyse tot dusver (28.425 kinderen voor bloeddruk, 22.565 voor hartfrequentie, 4-17 jaar) identificeerde acht genoombrede loci voor kinderbloeddruk en drie loci voor hartfrequentie — alle nieuw bij kinderen, eerder gezien bij volwassenen. Polygene risicoscores op kinderleeftijd verklaarden tot 1,6% van de BP- en 5,2% van de HF-variantie. In de UK Biobank waren hogere kinder-BP-PRS-niveaus geassocieerd met hypertensie, angina, myocardinfarct en cardiovasculaire mortaliteit op volwassen leeftijd. De resultaten ondersteunen vroegtijdige cardiovasculaire preventie.

## English: 

The largest paediatric GWAS meta-analysis to date (28,425 children for BP, 22,565 for heart rate, ages 4-17) identified eight genome-wide significant loci for childhood blood pressure and three for heart rate — all novel in children but previously reported in adults. Childhood polygenic risk scores explained up to 1.6% of BP and 5.2% of HR variance. In the UK Biobank, higher childhood-BP PRS levels were significantly associated with adult hypertension, angina, myocardial infarction and cardiovascular mortality — supporting cardiovascular prevention strategies that begin early in life.

## Abstract (original, from the publication)

BACKGROUND AND AIMS: To elucidate the genetic architecture of blood pressure (BP) and heart rate (HR) during early life and assess their potential relevance to adult health outcomes. METHODS: The largest genome-wide association study (GWAS) meta-analyses to date of childhood systolic BP, diastolic BP, pulse pressure, and mean arterial pressure (n = 28 425) and HR (n = 22 565) were conducted in children of European ancestry aged 4-17 years. Follow-up analyses included comparisons with adult GWAS results, polygenic risk score (PRS) analyses in independent cohorts of diverse ancestries, and a phenome-wide association study in the UK Biobank. RESULTS: Eight genome-wide significant loci were identified for childhood BP (KIAA2013, CACNB2, PLCE1, PAX2, COL4A2, RP11-236L14.1, CFDP1, TPX2) and three loci for childhood HR (CCDC141, ACHE, MYH6); all novel in children but previously reported in adults. Childhood PRSs explained up to 1.6% of BP variance and 5.2% of HR variance among children of European ancestry. Genetic correlations between childhood and adulthood BP traits were moderate (rg = 0.4-0.7), suggesting age-specific genetic effects on BP. In the UK Biobank, higher childhood BP PRS levels were significantly associated with a broad range of adult health outcomes, particularly cardiometabolic outcomes such as hypertension, angina, myocardial infarction, and cardiovascular disease-related mortality. CONCLUSIONS: These findings advance the understanding of the genetic architecture of childhood BP and HR and provide compelling genetic evidence linking childhood BP to a broad spectrum of adult health outcomes-particularly cardiometabolic conditions-which may inform targeted prevention strategies from a young age.

Auteurs: Tian Xie, Alireza Ani, Ahmad Vaez, Ilja M Nolte, Shaoyong Su, Mami Ishikuro, Siqi Wang, Wenbo Zhang, Ana Goncalves Soares, Ehsan Motazedi, Lucinda Calas, Justiina Ronkainen, Casper-Emil T Pedersen, Xueling Lu, Sara E Stinson, Janine F Felix, Evelina Stankevic, Carol A Wang, Elisabeth Thiering, Dietmar Fernández, Beatriz Calvo-Serra, Maria G Stathopoulou, Ruby Fore, Ashish Kumar, Johanna Tuhkanen, Jose Ramon Bilbao, Jesus Ibarluzea, Aaron Isaacs, Cilius Esmann Fonvig, Fernando Rivadeneira, Morten Asp Vonsild Lund, Louise Aas Holm, Peter J van der Most, Harriëtte Riese, Akira Narita, Gen Tamiya, Claudia Flexeder, Rikstje Wiersma, Anna D Argoty-Pantoja, Rebecca Vinding, Tine Willum Hansen, Thomas Kümler, Marisa Estarlich, Mariona Bustamante, Wen Lun Yuan, Anne Boland-Augé, Jean-François Deleuze, Alexandros M Petrelis, Sheryl Rifas-Shiman, Eero Kajantie, Nora Fernandez-Jimenez, Loreto Santa-Marina, Ilja C W Arts, Jari Lahti, Timo Strandberg, Inger Kull, Anna Bergström, Marie-France Hivert, Klaus Bønnelykke, Shinichi Kuriyama, Lawrence J Beilin, Trevor A Mori, Catharina A Hartman, Niels Grarup, Carel Thijs, Katri Räikkönen, Erik Melén, Emily Oken, Sophie Visvikis-Siest, Kristine B Gützkow, Regina Grazuleviciene, Barbara Heude, Leda Chatzi, Martine Vrijheid, Marie Standl, Tanja Vrijkotte, Craig E Pennell, Albertine J Oldehinkel, Torben Hansen, Vincent W V Jaddoe, Jens-Christian Holm, Sylvain Sebert, Nicholas J Timpson, Taku Obara, Xiaoling Wang, Deborah A Lawlor, Eva Corpeleijn, Tarunveer S Ahluwalia, Harold Snieder

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Bron: European heart journal, https://doi.org/10.1093/eurheartj/ehag313. Bijgewerkt 2026-07-03T18:39:31Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.