{"id":"46011","type":"article","url":"https://hartvaat.nl/2026/04/29/fibromusculaire-dysplasie-nieuwe-inzichten-voorbij-de-2019-consensus-bredere-cla/","title":"Fibromusculaire dysplasie: nieuwe inzichten voorbij de 2019-consensus — bredere classificatie en biomarkers in zicht","title_en":"Fibromuscular Dysplasia: Emerging Concepts Beyond the International Consensus","category":"hypertensie","category_label":"Hypertensie","professions":["cardioloog","internist"],"tags":[],"journal":"Hypertension","doi":"https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25633","source_url":"https://doi.org/https://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.125.25633","authors":["Tom Robberechts"],"significance":6,"published":"2026-07-12","source_date":"2026-04-29","image":"","kennis":["https://hartvaat.nl/kennis/hypertensie/classificatie-bloeddruk-esc-2024/","https://hartvaat.nl/kennis/hypertensie/secundaire-hypertensie/"],"congress":"","summary_en":"Hypertension review of recent developments in fibromuscular dysplasia (FMD) since the First International Consensus document of 2019. The authors discuss: (1) a more detailed classification of FMD beyond the multifocal-versus-focal distinction, as a common language for research and clinical practice; (2) new insights into FMD-related phenotypes; (3) emerging imaging and proteomic biomarkers for improved detection, diagnosis, and classification, as well as prognosis and treatment response prediction; and (4) quantitative imaging with computational fluid dynamics (AI-enhanced or not) to assess the haemodynamic significance of FMD lesions. Combined with genetic studies and animal models, these developments pave the way for a more definitive and personalised approach to FMD.","created":"2026-07-03T20:27:05Z","updated":"2026-07-04T19:27:04Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Overzichtsartikel in Hypertension over recente ontwikkelingen rond fibromusculaire dysplasie (FMD) sinds het First International Consensus-document van 2019. De auteurs bespreken: (1) een uitgebreidere classificatie van FMD voorbij multifocale-versus-focale indeling, als gemeenschappelijke taal voor onderzoek en kliniek; (2) nieuwe inzichten in FMD-gerelateerde fenotypen; (3) opkomende beeldvormings- en proteomische biomarkers voor verbeterde detectie, diagnose en classificatie, alsmede prognose- en behandelvoorspelling; en (4) kwantitatieve beeldvorming met computational fluid dynamics (al dan niet versterkt door AI) om de hemodynamische betekenis van FMD-laesies te beoordelen. Samen met genetisch onderzoek en diermodellen banen deze ontwikkelingen de weg naar een meer definitieve en gepersonaliseerde aanpak van FMD.","abstract_original":"The First International Consensus on the diagnosis and management of fibromuscular dysplasia is a landmark document. Since its publication in 2019, important research has been ongoing in the field. In this review, we address current clinical challenges and discuss novel research approaches designed to overcome them. First, beyond the current distinction between multifocal and focal fibromuscular dysplasia (FMD), we propose a novel, more detailed and comprehensive classification of FMD and related diseases, which may be instrumental both as a research tool and as a common language between clinicians. Second, we discuss new information concerning phenotypes related to this condition. Third, we discuss the potential of emerging imaging and proteomic biomarkers to improve detection, diagnosis, and classification of FMD, as well as to predict prognosis and response to drugs or interventions. Finally, we describe promising novel approaches based on quantitative imaging, including computational fluid dynamics (enhanced or not by artificial intelligence), to assess the hemodynamic significance of FMD lesions. Along with further understanding of the genetics of FMD and animal models, these elements may allow for a more definite and personalized approach to this condition."}