{"id":"ac0e7e11488f","type":"article","url":"https://hartvaat.nl/2026/05/12/matige-koffiedrinken-waarschijnlijk-veilig-en-mogelijk-gunstig-bij-chronische-ni/","title":"Matige koffiedrinken waarschijnlijk veilig en mogelijk gunstig bij chronische nierziekte","title_en":"Coffee consumption and chronic kidney disease.","category":"chronische nierziekte","category_label":"Nierziekte","professions":["apotheker","huisarts","internist"],"tags":[],"journal":"Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association","doi":"10.1093/ndt/gfag107","source_url":"https://doi.org/10.1093/ndt/gfag107","authors":["Miguel Bigotte Vieira","Carla Nicolau","Andreia Curto","Rita Magriço","Finnian R Mc Causland","João Sérgio Neves"],"significance":5,"published":"2026-07-29","source_date":"2026-05-12","image":"","kennis":["https://hartvaat.nl/kennis/nierziekte/nierziekte-en-cardiovasculair-risico/","https://hartvaat.nl/kennis/nierziekte/nsaids-en-nierziekte/"],"congress":"","summary_en":"This narrative review synthesises current evidence on the relationship between caffeine intake, chronic kidney disease (CKD), and cardiovascular outcomes. The authors conclude that moderate coffee consumption is likely safe for patients with CKD and may offer potential renal and cardioprotective benefits. While these findings are reassuring, the evidence base remains largely observational, highlighting the need for more robust studies before formal clinical recommendations can be established. In practice, moderate coffee intake does not need to be restricted in most patients with chronic kidney disease.","created":"2026-07-22T00:52:53Z","updated":"2026-08-10T10:38:04Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Deze narratieve review synthetiseert de huidige evidentie over de relatie tussen cafeïneconsumptie, chronische nierziekte (CKD) en cardiovasculaire aandoeningen. Onderzoek suggereert dat matig koffiedrinken waarschijnlijk veilig is voor patiënten met CKD en mogelijk zelfs een gunstig effect kan hebben op nier- en hartgezondheid. Hoewel de bevindingen geruststellend zijn, wijzen auteurs op de noodzaak van sterker bewijs voordat er eenduidige klinische richtlijnen kunnen worden opgesteld. Voor de dagpraktijk betekent dit dat matige consumptie over het algemeen niet afgeraden hoeft te worden bij nierpatiënten.","abstract_original":"Coffee is one of the most widely consumed beverages globally. Caffeine has been linked to antioxidant, anti-inflammatory, antifibrotic, and anticancer effects. However, the relationship between caffeine consumption and the risk of chronic kidney disease (CKD) has yielded conflicting findings. Research on the health effects of caffeine relies mainly on exploratory observational studies, which may be affected by biases such as residual confounding. Variations in behaviour, health status, intake, and metabolism also influence outcomes. A comprehensive understanding of the mechanisms and population-specific factors mediating the impact of caffeine on kidney health is essential. In this article, we describe the metabolism and mechanism of action of caffeine, as well as its potential adverse effects. We synthesize current evidence and clarify the complex relationship between caffeine, CKD, and cardiovascular disease. Current evidence suggests that moderate caffeine intake is probably safe in CKD and may be potentially beneficial. Stronger evidence is needed before robust recommendations can be made for clinical practice."}