{"id":"e82d0391a444","type":"article","url":"https://hartvaat.nl/2026/05/13/aasi-is-geen-betrouwbare-maat-voor-arteriele-stijfheid-bij-kinderen-met-risico-o/","title":"AASI is geen betrouwbare maat voor arteriële stijfheid bij kinderen met risico op secundaire hypertensie","title_en":"","category":"hypertensie","category_label":"Hypertensie","professions":["cardioloog","internist"],"tags":["acuut-hartfalen","aperitif-trial","bloeddrukbehandeling","perifeer-vaatlijden","sacubitril-valsartan","voeding-hart","vrouwen"],"journal":"European journal of pediatrics","doi":"10.1007/s00431-026-07057-4","source_url":"https://doi.org/10.1007/s00431-026-07057-4","authors":["Plamen Bokov","Elodie Surget","Cherine Benzouid","Benjamin Dudoigon","Julien Hogan","Christophe Delclaux"],"significance":5,"published":"2026-06-21","source_date":"2026-05-13","image":"https://hartvaat.nl/global/img/cfa5359c05fb.webp","kennis":["https://hartvaat.nl/kennis/hypertensie/bloeddrukmeting-thuismeting-abpm/","https://hartvaat.nl/kennis/hypertensie/hypertensie-en-ckd/"],"congress":"","summary_en":"Cross-sectional study in 75 children and adolescents (8-18 years, mean 12.3; 34 girls) at risk of secondary hypertension: vascular remodeling context (preterm birth n=44, CKD n=7) or hyperkinetic causes (congenital central hypoventilation syndrome n=14, psychostimulant treatment n=10). Alongside 24-hour ambulatory BP monitoring (ABPM), arterial stiffness was measured by several methods: carotid-femoral and heart-finger pulse wave velocity, augmentation index (AIx75), and systemic arterial stiffness via pulse-contour analysis. AASI correlated with none of the direct stiffness measures, only with systolic and diastolic nocturnal BP dipping. In ABPM-hypertensive children (20%), cf-PWV was elevated (5.64 vs 4.92 m/s) but AASI was not. Conclusion: AASI does not reflect true arterial stiffness in children and should not be used as such.","created":"2026-07-03T10:33:05Z","updated":"2026-07-03T18:39:35Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Cross-sectionele studie bij 75 kinderen en adolescenten (8-18 jaar, gemiddelde 12,3 jaar; 34 meisjes) met risico op secundaire hypertensie: vasculaire remodeling-context (prematuur geboren n=44, CKD n=7) of hyperkinetische oorzaak (centraal congenitaal hypoventilatie-syndroom n=14, psychostimulantia n=10). Naast 24-uurs ambulante bloeddrukmeting (ABPM) werd arteriële stijfheid gemeten via meerdere methoden: carotido-femorale en heart-finger pulse wave velocity, augmentation index (AIx75) en systemische arteriële stijfheid via pulse-contouranalyse. AASI correleerde met geen van de directe stijfheidsmaten, alleen met systolische en diastolische BP-dipping 's nachts. Bij ABPM-hypertensieven (20%) was cf-PWV verhoogd (5,64 vs 4,92 m/s) maar AASI niet. Conclusie: AASI weerspiegelt bij kinderen geen werkelijke arteriële stijfheid en moet niet als zodanig worden gebruikt.","abstract_original":"UNLABELLED: The ambulatory arterial stiffness index (AASI) has emerged as an ambulatory blood pressure monitoring (ABPM) measure of stiffness and is supposedly useful in younger subjects. The objective of our study was to evaluate the relationships between the AASI and indices of arterial stiffness in a pediatric population at risk of hypertension. Cross-sectional study of children/adolescents (8-18 years) whose pulse wave velocity (PWV: carotid-to-femoral cf-PWV and heart-finger hf-PWV), augmentation index (AIx; normalized at 75 bpm: AIx75), systemic arterial stiffness (aortic pulse pressure/stroke volume, measured via pulse contour analysis), and ABPM were measured. At-risk populations were potential vascular remodeling (preterm birth, n = 44 and chronic kidney diseases, n = 7) and potential hyperkinetic causes (congenital central hypoventilation syndrome, n = 14 and psychostimulant treatment, n = 10). The mean age of the 75 participants was 12.3 ± 2.5 years (34 girls), and their mean AASI was 0.33 ± 0.17. AASI did not correlate with cf-PWV, hf-PWV, AIx, or systemic arterial stiffness. In contrast, the AASI correlated with both systolic and diastolic BP dipping at night (R =  - 0.23; p = 0.048 and R =  - 0.33; p = 0.004, respectively). Systemic arterial stiffness correlated with hf-PWV and AIx75 (R = 0.35; p = 0.004 and R =  - 0.34; p = 0.013, respectively). Based on ABPM, 15/75 (20%) participants had hypertension, and they had higher cf-PWV than participants without hypertension (5.64 ± 0.70 vs 4.92 ± 0.78 m/s, p = 0.002) and not different AASI values (0.34 ± 0.14 vs 0.32 ± 0.18, p = 0.756). CONCLUSION: AASI is not a measure of arterial stiffness in children at risk of secondary hypertension. WHAT IS KNOWN: • The ambulatory arterial stiffness index (AASI) has emerged as an ambulatory blood pressure monitoring measure of stiffness and is supposedly useful in younger subjects. Few adult studies validated the concept of AASI as a marker of arterial stiffness, and recent studies suggested the need for AASI measurement in pediatric subjects. WHAT IS NEW: • Our cross-sectional study, which used different methods for the assessment of vascular remodeling, shows that the AASI is not a reliable marker of arterial stiffness in children at risk of secondary hypertension."}