{"id":"f9595340a3e8","type":"article","url":"https://hartvaat.nl/2026/05/13/uk-biobank-na-ischemisch-cva-of-tia-is-het-risico-op-hartfalen-groter-dan-dat-op/","title":"UK Biobank: na ischemisch CVA of TIA is het risico op hartfalen groter dan dat op een infarct","title_en":"","category":"hartfalen","category_label":"Hartfalen","professions":["cardioloog","huisarts","internist"],"tags":["cerebrovasculair","heart-failure-2026"],"journal":"ESC Heart Failure","doi":"10.1093/eschf/xvag123","source_url":"https://doi.org/10.1093/eschf/xvag123","authors":["Rahul G. Muthalaly","Nitesh Nerlekar","Sean Tan","Andrew Lin","Adam J. Nelson"],"significance":7,"published":"2026-05-15","source_date":"2026-05-13","image":"","kennis":["https://hartvaat.nl/kennis/hartfalen/hartfalen-polikliniek-opzet/","https://hartvaat.nl/kennis/diagnostiek/cardiale-mri/"],"congress":"heart-failure-2026","summary_en":"UK Biobank cohort (n=405,406, age 40–69, 13.7-y follow-up) shows ischaemic stroke/TIA survivors face crude HR 3.6 (adjusted 1.4) for HF hospitalization. Notably, HF hospitalization risk (12.6%) exceeds subsequent MI risk (5.4%) in this group. Lower LVEF and higher LV mass on CMR among those who develop HF. Incident HF after stroke carries HR 1.8 for mortality. Argues for systematic cardiac follow-up of stroke survivors with structured HF risk assessment.","created":"2026-07-03T10:32:56Z","updated":"2026-07-03T13:31:51Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Prospectieve UK Biobank-analyse (n=405.406, leeftijd 40-69 jaar bij inclusie, 13,7 jaar follow-up) na exclusie van mensen met al bekend hartfalen, gestratificeerd naar voorgeschiedenis van ischemisch CVA of TIA. Bij overlevenden van CVA/TIA was de ongecorrigeerde HR voor hartfalen-opname 3,6 (95% BI 3,3-3,8; p<0,0001); na correctie HR 1,4 (95% BI 1,3-1,5; p<0,0001). Opvallend: bij CVA-overlevenden lag het cumulatieve risico op hartfalen-opname (12,6%) hoger dan op myocardinfarct (5,4%). CMR-data tonen lagere LVEF en hogere LV-massa bij CVA-overlevenden die later hartfalen ontwikkelen. Incident hartfalen na CVA was geassocieerd met HR 1,8 voor mortaliteit. Conclusie: incident hartfalen is een hoofdoorzaak van morbiditeit en mortaliteit na CVA/TIA — vaker dan een nieuw infarct — en rechtvaardigt systematische cardiale follow-up met gestructureerde hartfalen-risicobeoordeling bij deze populatie. Relevant voor de Nederlandse multidisciplinaire CVA-zorgketens.","abstract_original":"Aims: To define incident heart failure (HF) risk in ischaemic stroke/TIA survivors. Secondary aims: to define the association of HF with all-cause mortality in stroke survivors and to describe their cardiac magnetic resonance findings. Methods: Prospective cohort study using the UK Biobank cohort (aged 40–69 years), excluding individuals with prior HF. Participants were stratified by history of ischaemic stroke/TIA. Main outcome: incident HF as defined by hospital admissions coded for HF. Secondary outcomes: all-cause mortality, myocardial infarction and CMR findings. Results: 405,406 individuals were included (mean age 56.5 years, 45.6% males). Over 13.7 years of follow-up, 15,565 individuals developed incident HF. Stroke/TIA survivors had a crude HR 3.6 (95% CI 3.3–3.8; p<0.0001) for HF hospitalization, attenuated to adjusted HR 1.4 (95% CI 1.3–1.5; p<0.0001). The risk of HF hospitalization exceeded the risk of MI (12.6% vs 5.4%). Stroke survivors with subsequent HF had lower LVEF and higher LV mass on CMR than those without HF. Incident HF after stroke was associated with HR 1.8 (95% CI 1.6–1.9) for mortality. Conclusions: Incident HF is common in stroke survivors and strongly associates with mortality. The risk of HF exceeds the risk of subsequent MI — a counter-intuitive finding that argues for systematic cardiac follow-up of stroke survivors with structured HF risk assessment."}