{"id":"fc15d042418b","type":"article","url":"https://hartvaat.nl/2026/05/19/peulvruchten-in-de-voeding-verlagen-ldl-en-non-hdl-dose-response-meta-analyse-va/","title":"Peulvruchten in de voeding verlagen LDL en non-HDL: dose-response meta-analyse van 38 RCT's","title_en":"","category":"cholesterol","category_label":"Cholesterol","professions":["cardioloog","huisarts","internist"],"tags":["bempedoïnezuur","cetp-remmers","dyslipidemie","ezetimibe","familiaire-hypercholesterolemie","familiaire-hypercholesterolemie-screening","hdl-cholesterol","ldl-cholesterol","lipidenverlaging","niet-statine-therapie","soul-trial","statines"],"journal":"Journal of the American Heart Association","doi":"10.1161/JAHA.125.046659","source_url":"https://doi.org/10.1161/JAHA.125.046659","authors":["Songhee Back","Shuting Yang","Antonio Rossi","Sabrina Ayoub-Charette","Shannan M Grant","Victoria Chen","Erika J Lin","Lukas Haintz","Yue-Tong Chen","Elmirah Ahmad","Jacqueline Gahagan","Christopher P F Marinangeli","Vanessa Ha","Tauseef Ahmad Khan","Sonia Blanco Meji","Andreea Zurbau","Russell J de Souza","Joseph Beyene","Marcia M English","Vladimir Vuksan","Robert G Josse","Lawrence A Leiter","Cyril W C Kendall","David J A Jenkins","John L Sievenpiper","Laura Chiavaroli"],"significance":7,"published":"2026-06-13","source_date":"2026-05-19","image":"","kennis":["https://hartvaat.nl/kennis/lipiden/dyslipidemie-overzicht/","https://hartvaat.nl/kennis/lipiden/hdl-functie-en-reverse-cholesterol/"],"congress":"","summary_en":"Systematic review and dose-response meta-analysis of 38 randomised trials (52 comparisons, n=2,095) on the effect of whole dietary pulses on lipid targets. Median duration 6 weeks, median dose 130 g/day (0.5-0.67 cup). Pulses reduced LDL cholesterol by -0.14 mmol/L (95% CI -0.19 to -0.08), non-HDL cholesterol by -0.22 mmol/L, apoB by -0.08 g/L, and HDL by -0.03 mmol/L (the last clinically trivial). No effect on other lipids. Results were consistent across pulse types. For beans, a linear inverse relationship was demonstrated up to 1 cup/day for LDL (-0.25 mmol/L per 0.5 cup) and non-HDL (-0.45 mmol/L per 0.5 cup). GRADE certainty was moderate-to-high for most outcomes. Effects are small-to-moderate but clinically meaningful, supporting dietary guidelines on pulses as a lipid-lowering strategy.","created":"2026-07-03T10:33:02Z","updated":"2026-07-03T13:31:57Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Systematische review en dose-response meta-analyse van 38 gerandomiseerde studies (52 vergelijkingen, totaal n=2.095) over het effect van complete peulvruchten op lipidendoelen. Mediane duur 6 weken, mediane dosis 130 g/dag (0,5-0,67 cup). Peulvruchten verlaagden LDL-cholesterol met -0,14 mmol/L (95%-BI -0,19 tot -0,08), non-HDL-cholesterol met -0,22 mmol/L, apoB met -0,08 g/L en HDL met -0,03 mmol/L (laatste effect klinisch verwaarloosbaar). Geen effect op overige lipiden. Resultaten waren consistent over peulvruchttypen. Voor bonen werd een lineair invers verband aangetoond tot 1 cup/dag voor LDL (-0,25 mmol/L per 0,5 cup) en non-HDL (-0,45 mmol/L per 0,5 cup). GRADE-zekerheid was matig-tot-hoog voor de meeste uitkomsten. De effecten zijn klein-tot-matig maar klinisch betekenisvol en ondersteunen voedingsrichtlijnen over peulvruchten als lipidenverlagende strategie.","abstract_original":"BACKGROUND: Although dietary pulses are recognized by major clinical practice guidelines to reduce cholesterol and coronary heart disease risk, intake is low. There are no health claims for any pulse for cholesterol reduction, which could support uptake. We therefore conducted a systematic review and dose-response meta-analysis of randomized trials of the effect of different types of whole dietary pulses on lipid targets. METHODS: MEDLINE, Embase, and the Cochrane Library were searched through March 2025 for trials ≥3 weeks. The primary outcome was low-density lipoprotein-cholesterol. Secondary outcomes were other lipid targets. Independent reviewers extracted data and assessed risk of bias. Certainty of evidence was assessed using Grading of Recommendations Assessment, Development, and Evaluation. RESULTS: Thirty-eight trials (52 trial comparisons, n=2095) with a median of 6 weeks and dose of 130 g/d (0.5-0.67 cup/d) showed that whole dietary pulses decreased low-density lipoprotein-cholesterol (mean difference, -0.14 mmol/L [95% CI, -0.19 to -0.08]), non-high-density lipoprotein-cholesterol (-0.22 mmol/L [95% CI, -0.30 to -0.14]), apoB (apolipoprotein B) (-0.08 g/L [95% CI, -0.13 to -0.03]) and high-density lipoprotein-cholesterol (-0.03 mmol/L [95% CI, -0.05 to -0.01]) with no effects on other lipids. Analyses by pulse type showed similar results. A linear inverse relationship was shown for beans up to 1 cup/d for low-density lipoprotein-cholesterol (coefficient, -0.25 mmol/L/0.5 cup [95% CI, -0.48 to -0.02]) and non-high-density lipoprotein-cholesterol (-0.45 mmol/L/0.5 cup [95% CI, -0.71 to -0.18]). Grading of Recommendations Assessment, Development, and Evaluation was moderate-to-high for all outcomes, except apoB (very low). CONCLUSIONS: Whole dietary pulses likely result in small important-to-moderate reductions in lipid targets and trivial reductions in high-density lipoprotein-cholesterol. Similar effects were observed across pulse types with an inverse dose-response gradient for beans up to 1 cup/d. Future studies on chickpeas, dried peas, and lentils are warranted. REGISTRATION: URL: https://www.crd.york.ac.uk/PROSPERO/view/CRD42023432826; Unique identifier: CRD42023432826."}