{"id":"78b504a8eab6","type":"article","url":"https://hartvaat.nl/2026/05/28/atriumfibrilleren-en-hartfalen-versterken-elkaar-en-verhogen-sterfte-aanzienlijk/","title":"Atriumfibrilleren en hartfalen versterken elkaar en verhogen sterfte aanzienlijk — UK Biobank","title_en":"Development of Atrial Fibrillation in patients with Heart Failure and vice versa: Incidence, risk factors, and their impact on survival.","category":"hartfalen","category_label":"Hartfalen","professions":["cardioloog","huisarts"],"tags":[],"journal":"ESC heart failure","doi":"10.1093/eschf/xvag152","source_url":"https://doi.org/10.1093/eschf/xvag152","authors":["Arietje J L Zandijk","Hailun Qin","Jasper Tromp","Michiel Rienstra","Adriaan A Voors"],"significance":5,"published":"2026-07-28","source_date":"2026-05-28","image":"","kennis":[],"congress":"","summary_en":"A UK Biobank cohort study of 31,374 participants demonstrates a strong bidirectional relationship between atrial fibrillation (AF) and heart failure (HF): AF increases the risk of subsequent HF by threefold, while HF raises the risk of AF by 2.75 times. Patients with both conditions face a substantially higher mortality risk compared to those with either condition alone, regardless of which disease developed first. These findings highlight the need for proactive prevention strategies and close monitoring in both AF and HF populations to interrupt this harmful cycle.","created":"2026-07-20T01:12:25Z","updated":"2026-08-10T10:38:13Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Een cohortstudie onder 31.374 deelnemers van de UK Biobank toont aan dat atriumfibrilleren (AF) en hartfalen (HF) elkaar sterk beïnvloeden: patiënten met AF hebben een drie keer hoger risico op HF, terwijl HF-patiënten een 2,75 keer hoger risico op AF lopen. De combinatie van beide aandoeningen verdubbelt of verveelvoudigt de sterftekans, ongeacht welke ziekte eerst optreedt. Deze bevindingen onderstrepen het belang van vroegtijdige preventie en intensieve monitoring bij patiënten met AF of HF om de ontwikkeling van de andere aandoening tegen te gaan.","abstract_original":"AIMS: Atrial fibrillation (AF) and heart failure (HF) frequently coexist, and their combination is associated with poorer outcomes. The bidirectional risk and the impact of which disease develops first on mortality remains unclear. METHODS: We studied 31,374 UK Biobank participants with new-onset AF or HF (2006-2022). Multivariable Cox models assessed risk factors, incidence, and mortality risk. RESULTS: The risk of developing HF was higher in patients with AF than in those without AF (45.1 vs 3.87 per 1000 person-years; aHR 3.15, 95% CI 3.0-3.31). The risk of developing AF in patients with HF was higher than in those without HF (25.4 vs. 2.27 per 1000 person-years; aHR 2.75, 95% CI 2.62 - 2.90). HF patients had a 31% higher risk of subsequent AF, compared to the risk of AF patients developing HF (p<0.05). Mortality risk was substantially higher in patients with both conditions. AF before HF conferred a nearly fourfold increased risk (aHR 3.8, 95% CI 3.5-4.2), while HF before AF more than doubled risk (aHR 2.0, 95% CI 2.1-2.6), compared to either condition alone. Regardless of which disease was diagnosed first, there was no significant difference in mortality risk (aHR 0.95, 95% CI 0.85-1.07). CONCLUSIONS: AF and HF strongly predispose to each other, with HF conferring a higher relative risk for incident AF. The coexistence of both diseases substantially increases mortality regardless of which disease developed first, emphasizing the need for strategies to prevent the development of HF in patients with AF and vice versa."}