{"id":"172253cf7b60","type":"article","url":"https://hartvaat.nl/2026/06/27/laag-cachexie-index-voorspelt-overleving-en-heropname-bij-hartfalenpatienten/","title":"Laag cachexie-index voorspelt overleving en heropname bij hartfalenpatiënten","title_en":"The Prognostic Impact of the Cachexia Index in Patients Hospitalized with Heart Failure.","category":"hartfalen","category_label":"Hartfalen","professions":["cardioloog","internist"],"tags":[],"journal":"Medicina (Kaunas, Lithuania)","doi":"10.3390/medicina62071246","source_url":"https://doi.org/10.3390/medicina62071246","authors":["Vahit Can Cavdar","Hidayet Ozan Arabaci","Zafer Guven","Emine Meltem","Hatice Ozkul","Ayse Satilmisoglu","Kader Onay","Elif Kilic Dinler","Ismail Can Ciftci","Yalcin Gokmen","Mert Aric","Ayli Heydari","Cagdas Kaya","Veysi Kapagan","Eser Onur Cakir","Ahmet Oz"],"significance":4,"published":"2026-08-05","source_date":"2026-06-27","image":"","kennis":["https://hartvaat.nl/kennis/diagnostiek/cardiale-ct-coronaire-calcium-score/","https://hartvaat.nl/kennis/diagnostiek/galectine-3-st2-hartfalen/"],"congress":"","summary_en":"In a retrospective single-center cohort of 127 patients hospitalized for decompensated heart failure, a low cachexia index (CXI)—calculated from skeletal muscle mass, serum albumin, and the neutrophil-to-lymphocyte ratio—was strongly associated with all-cause mortality and recurrent hospitalizations. Patients with a CXI below 20.87 had a mortality rate of 80.5% and a median of 4 heart failure-related readmissions, compared to 4.7% mortality and 0.5 readmissions in those with a high CXI. While the CXI shows promise as an integrative prognostic tool for risk stratification, its clinical utility requires validation in larger, multicenter prospective studies.","created":"2026-07-30T01:08:29Z","updated":"2026-08-10T10:36:57Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"In een retrospectief eencentrumonderzoek bij 127 patiënten met een hartfalenexacerbatie bleek een lage cachexie-index (CXI), gebaseerd op spiermassa, albumine en het neutrofiel-lymfocytenquotiënt, sterk geassocieerd met overlijden en heropname. Patiënten met een CXI < 20,87 hadden een overlevingskans van slechts 4,7% tegen 80,5% bij een hoge CXI, en ondergingen gemiddeld 4 heropnames versus 0,5. Hoewel de CXI een nuttige prognostische marker lijkt te zijn voor risicostratificatie, blijft de klinische toepassing beperkt door het eencentrum- en retrospectieve karakter van het onderzoek.","abstract_original":"Background and Objectives: Cachexia is a systemic wasting syndrome associated with poor outcomes in chronic diseases, including heart failure (HF). Although the cachexia index (CXI), which integrates skeletal muscle mass, serum albumin, and the neutrophil-to-lymphocyte ratio, has shown prognostic value in oncology, its clinical significance in HF remains poorly defined. Materials and Methods: This retrospective single-center cohort study evaluated a selected subgroup of adults hospitalized with decompensated heart failure between January 2020 and January 2025 who had undergone abdominal computed tomography within the preceding 6 months, enabling CT-based body composition assessment. Skeletal muscle index was measured at the L3 vertebral level, and CXI was calculated as (SMI × serum albumin)/neutrophil-to-lymphocyte ratio. Patients were followed for all-cause mortality and HF-related rehospitalizations. Results: A total of 127 patients were included (mean age 70.45 ± 12.73 years; 51.2% male). CXI showed excellent discrimination for mortality (AUC 0.951; 95% CI 0.905-0.996), with an optimal cut-off value of <20.87. Patients with low CXI had significantly higher all-cause mortality (80.5% vs. 4.7%, p < 0.001) and more HF-related hospitalizations [4 (3-5) vs. 0.5 (0-1), p < 0.001] than those with high CXI. Conclusions: In patients hospitalized with decompensated HF, low CXI was strongly associated with all-cause mortality and recurrent hospitalization, suggesting that CXI may serve as an integrative prognostic marker in this population."}