# Laag cachexie-index voorspelt overleving en heropname bij hartfalenpatiënten

*geplaatst 2026-08-05 · Hartfalen · Medicina (Kaunas, Lithuania) · doi 10.3390/medicina62071246 · https://hartvaat.nl/2026/06/27/laag-cachexie-index-voorspelt-overleving-en-heropname-bij-hartfalenpatienten/*

In een retrospectief eencentrumonderzoek bij 127 patiënten met een hartfalenexacerbatie bleek een lage cachexie-index (CXI), gebaseerd op spiermassa, albumine en het neutrofiel-lymfocytenquotiënt, sterk geassocieerd met overlijden en heropname. Patiënten met een CXI < 20,87 hadden een overlevingskans van slechts 4,7% tegen 80,5% bij een hoge CXI, en ondergingen gemiddeld 4 heropnames versus 0,5. Hoewel de CXI een nuttige prognostische marker lijkt te zijn voor risicostratificatie, blijft de klinische toepassing beperkt door het eencentrum- en retrospectieve karakter van het onderzoek.

## English: The Prognostic Impact of the Cachexia Index in Patients Hospitalized with Heart Failure.

In a retrospective single-center cohort of 127 patients hospitalized for decompensated heart failure, a low cachexia index (CXI)—calculated from skeletal muscle mass, serum albumin, and the neutrophil-to-lymphocyte ratio—was strongly associated with all-cause mortality and recurrent hospitalizations. Patients with a CXI below 20.87 had a mortality rate of 80.5% and a median of 4 heart failure-related readmissions, compared to 4.7% mortality and 0.5 readmissions in those with a high CXI. While the CXI shows promise as an integrative prognostic tool for risk stratification, its clinical utility requires validation in larger, multicenter prospective studies.

## Abstract (original, from the publication)

Background and Objectives: Cachexia is a systemic wasting syndrome associated with poor outcomes in chronic diseases, including heart failure (HF). Although the cachexia index (CXI), which integrates skeletal muscle mass, serum albumin, and the neutrophil-to-lymphocyte ratio, has shown prognostic value in oncology, its clinical significance in HF remains poorly defined. Materials and Methods: This retrospective single-center cohort study evaluated a selected subgroup of adults hospitalized with decompensated heart failure between January 2020 and January 2025 who had undergone abdominal computed tomography within the preceding 6 months, enabling CT-based body composition assessment. Skeletal muscle index was measured at the L3 vertebral level, and CXI was calculated as (SMI × serum albumin)/neutrophil-to-lymphocyte ratio. Patients were followed for all-cause mortality and HF-related rehospitalizations. Results: A total of 127 patients were included (mean age 70.45 ± 12.73 years; 51.2% male). CXI showed excellent discrimination for mortality (AUC 0.951; 95% CI 0.905-0.996), with an optimal cut-off value of <20.87. Patients with low CXI had significantly higher all-cause mortality (80.5% vs. 4.7%, p < 0.001) and more HF-related hospitalizations [4 (3-5) vs. 0.5 (0-1), p < 0.001] than those with high CXI. Conclusions: In patients hospitalized with decompensated HF, low CXI was strongly associated with all-cause mortality and recurrent hospitalization, suggesting that CXI may serve as an integrative prognostic marker in this population.

Auteurs: Vahit Can Cavdar, Hidayet Ozan Arabaci, Zafer Guven, Emine Meltem, Hatice Ozkul, Ayse Satilmisoglu, Kader Onay, Elif Kilic Dinler, Ismail Can Ciftci, Yalcin Gokmen, Mert Aric, Ayli Heydari, Cagdas Kaya, Veysi Kapagan, Eser Onur Cakir, Ahmet Oz

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Bron: Medicina (Kaunas, Lithuania), https://doi.org/10.3390/medicina62071246. Bijgewerkt 2026-08-10T10:36:57Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.