{"id":"9911af4b1d4a","type":"article","url":"https://hartvaat.nl/2026/06/30/infectieuze-endocarditis-verschuiving-naar-oudere-patienten-met-comorbiditeiten-/","title":"Infectieuze endocarditis: verschuiving naar oudere patiënten met comorbiditeiten en medische hulpmiddelen","title_en":"Changing Patterns in Infective Endocarditis: A Contemporary Epidemiological Perspective.","category":"algemeen","category_label":"Algemeen","professions":["cardioloog","internist"],"tags":[],"journal":"Pathogens (Basel, Switzerland)","doi":"10.3390/pathogens15070697","source_url":"https://doi.org/10.3390/pathogens15070697","authors":["Vasiliki Rapti","Anna-Pelagia Magiorakos","Efthymia Giannitsioti","Garyfallia Poulakou"],"significance":4,"published":"2026-08-04","source_date":"2026-06-30","image":"","kennis":["https://hartvaat.nl/kennis/kleplijden/endocarditis-profylaxe/","https://hartvaat.nl/kennis/kleplijden/kleplijden-en-zwangerschap/"],"congress":"","summary_en":"This narrative review outlines the shifting epidemiology of infective endocarditis (IE), highlighting a transition from younger patients with structural heart disease to older individuals with multiple comorbidities and frequent healthcare exposure. The increasing prevalence of end-stage renal disease, immunosuppression, intravenous drug use, and implanted cardiac devices has broadened the susceptible population and altered microbiological patterns, with staphylococci and enterococci now dominating. Clinicians should recognize this evolving risk profile, as it necessitates targeted prevention strategies around prosthetic valves and cardiac devices, alongside a heightened index of suspicion in complex, multimorbid patients.","created":"2026-07-29T00:58:27Z","updated":"2026-08-10T10:37:11Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Deze narratieve review schetst de veranderende epidemiologie van infectieuze endocarditis (IE), waarbij de patiëntenpopulatie verschuift van jongeren met aangeboren hartafwijkingen naar ouderen met multiple comorbiditeiten en frequente zorgcontacten. Factoren zoals veroudering, nierfalen, immunosuppressie, intraveneus druggebruik en de groeiende inzet van prothetische kleppen en cardiale hulpmiddelen hebben het ziektebeeld en de microbiologische patronen (vooral staphylo- en enterokokken) ingrijpend veranderd. Voor de klinische praktijk betekent dit dat IE steeds vaker voorkomt in complexe patiëntgroepen, wat aandacht vraagt voor preventie rondom medische hulpmiddelen en een breder diagnostisch en therapeutisch kader.","abstract_original":"Since its first description in the late nineteenth century, the epidemiology of infective endocarditis (IE) has changed considerably. Once primarily affecting younger individuals with structural heart disease, IE is now increasingly encountered in older patients with multiple comorbidities and frequent healthcare exposure. Population ageing, end-stage renal disease (ESRD), immunosuppression, and injection drug use (IDU) have broadened the pool of susceptible hosts. At the same time, the increasing use of prosthetic valves (PVs), cardiac implantable electronic devices (CIEDs), and transcatheter cardiac interventions has reshaped the clinical spectrum of IE. This epidemiological transition has also been accompanied by shifts in microbiological patterns, with a growing predominance of staphylococci and enterococci, as well as marked geographic and socioeconomic variation in disease burden. This review summarizes the contemporary epidemiology of IE, with an emphasis on the host-, healthcare-, and microbiological factors underlying its evolving clinical profile."}