{"id":"26bd7b14c65f","type":"article","url":"https://hartvaat.nl/2026/07/30/visinname-en-visgerelateerde-metabolieten-geassocieerd-met-lagere-triglyceriden-/","title":"Visinname en visgerelateerde metabolieten geassocieerd met lagere triglyceriden en bloeddruk","title_en":"Association between fish-related metabolites and metabolic syndrome risk factors in Japan: INTERLIPID metabolome -wide association study.","category":"cholesterol","category_label":"Cholesterol","professions":["huisarts","internist"],"tags":[],"journal":"European journal of nutrition","doi":"10.1007/s00394-026-04068-7","source_url":"https://doi.org/10.1007/s00394-026-04068-7","authors":["Tserenlkham Byambajav","Queenie Chan","Yukiko Okami","Aya Kadota","Naoko Miyagawa","Nagako Okuda","Hideaki Nakagawa","Kiyomi Sakata","Shigeyuki Saitoh","Akira Okayama","Katsushi Yoshita","Kamal Masaki","Chung-Ho E Lau","Timothy M Ebbels","Linda Van Horn","Elaine Holmes","Paul Elliott","Jeremiah Stamler","Hirotsugu Ueshima","Katsuyuki Miura"],"significance":3,"published":"2026-08-16","source_date":"2026-07-30","image":"https://hartvaat.nl/global/img/86584cdaf8b2.webp","kennis":["https://hartvaat.nl/kennis/lipiden/hdl-functie-en-reverse-cholesterol/","https://hartvaat.nl/kennis/preventie/esc-richtlijn-cardiovasculaire-preventie-2021/"],"congress":"","summary_en":"A cross-sectional study of 1,047 Japanese adults examined the relationship between fish intake, fish-related metabolites, and metabolic syndrome risk factors. Higher consumption of fish and shellfish was significantly associated with lower triglycerides, lower systolic blood pressure, and a more favorable HDL cholesterol profile. The results suggest that cooking methods may modulate the metabolic impact of seafood, offering nuanced insights for dietary counseling in cardiovascular and metabolic risk prevention.","created":"2026-08-09T01:39:11Z","updated":"2026-08-10T10:35:22Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Een cross-sectionele studie onder 1047 Japanse volwassenen onderzocht de relatie tussen visinname, gerelateerde metabolieten en risicofactoren voor metabool syndroom. Hogere inname van vis en schaal- en schelpdieren correleerde significant met lagere triglyceriden, lagere systolische bloeddruk en een gunstiger HDL-cholesterolprofiel. De bevindingen benadrukken dat de bereidingswijze van vis de metabolische impact kan beïnvloeden, wat relevant is voor leefstijladviezen in de preventieve zorg.","abstract_original":"BACKGROUND: Previous findings for the association of fish intake and its related metabolites on risk of metabolic syndrome (MetS) are inconsistent and limited. The prevalence of fish and shellfish consumers are high in Japan where it contributes to one fourth of the protein intake. We aimed to investigate the relationship of fish and fish-related metabolites with MetS risk factors in a community-dwelling Japanese population. METHODS: In this cross-sectional study, 1047 Japanese men and women aged 40-59 years were included. Four in-depth multiple-pass 24-h dietary recalls, two timed 24-h urine collections, blood collection, extensive questionnaire and anthropometric measurements were collected for each participant. Urinary and serum profiles were obtained using 1H Nuclear magnetic resonance (NMR) spectroscopy. RESULTS: Mean fish intake was 47.0 (SD 28.8) g per 1000 kcal. Urinary trimethylamine-N-oxide (TMAO) and taurine, and serum creatine and threonine were significantly correlated with fish intake and homarine was associated with shellfish intake (p < 0.01). Significant inverse associations were found between triglycerides and total fish intake, low omega-3 fish, urinary TMAO, taurine and between urinary taurine with systolic blood pressure. Direct association between urinary TMAO and serum threonine with high-density lipoprotein cholesterol were found. CONCLUSION: We found several metabolites related to fish intake and risk factors of MetS in habitual fish-consuming country, Japan. When stratified by seafood type, raw and high omega-3 fish intake showed the strongest associations with urinary and serum metabolomes, while fried fish had weaker or non-significant correlations, suggesting that cooking methods may modulate the bioavailability or metabolic impact of fish nutrients. The combined panel of urinary TMAO and taurine with plasma creatine and threonine, reflecting seafood intake, was associated with a favorable lipid profile and lower blood pressure. CLINICAL TRAIL REGISTRATION: The INTERMAP study is registered as NCT00005271 at www. CLINICALTRIALS: gov ."}