{"id":"7af1ba3f5882","type":"article","url":"https://hartvaat.nl/2026/07/31/uit-het-hospitaal-hartstilstand-komt-12-keer-vaker-voor-bij-niet-ischemische-car/","title":"Uit-het-hospitaal hartstilstand komt 12 keer vaker voor bij niet-ischemische cardiomyopathie — registerstudie","title_en":"Incidence, Analysis and Risk of Out-of-Hospital Cardiac Arrest in Individuals with Non-Ischaemic Dilated Cardiomyopathy.","category":"hartfalen","category_label":"Hartfalen","professions":["cardioloog","huisarts"],"tags":[],"journal":"ESC heart failure","doi":"10.1093/eschf/xvag207","source_url":"https://doi.org/10.1093/eschf/xvag207","authors":["Leo Henry Mansell","Peder Emil Warming","Rasmus Bork Dinesen","Rodrigue Garcia","Reza Jabbari","Gunnar Gislason","Bo Gregers Winkel","Jacob Tfelt-Hansen"],"significance":5,"published":"2026-08-16","source_date":"2026-07-31","image":"","kennis":["https://hartvaat.nl/kennis/hartfalen/ischemische-cardiomyopathie/","https://hartvaat.nl/kennis/diagnostiek/cardiale-mri/"],"congress":"","summary_en":"A nationwide Danish register study spanning two decades reveals that patients with non-ischaemic dilated cardiomyopathy (NIDCM) face a substantially higher risk of out-of-hospital cardiac arrest (OHCA) compared to the general population. The incidence rate is approximately 12 times higher (532 vs 45 per 100,000 person-years), with a 10-year cumulative risk of 3.4% in men and 2.1% in women. Although NIDCM-related arrests more frequently present with a shockable rhythm, 30-day and 1-year mortality remain comparable to non-NIDCM cases. These epidemiological insights assist cardiologists and primary care physicians in refining sudden cardiac death risk stratification and guiding preventive strategies, such as implantable cardioverter-defibrillator placement, in this distinct heart failure cohort.","created":"2026-08-09T01:35:12Z","updated":"2026-08-10T10:35:23Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Een Deense registerstudie onder meer dan 20 jaar data toont aan dat patiënten met niet-ischemische dilated cardiomyopathie (NIDCM) een aanzienlijk hoger risico lopen op een uit-het-hospitaal hartstilstand (OHCA) vergeleken met de algemene bevolking. Het incidentiebedrag ligt met 532 per 100.000 persoonjaren ongeveer 12 keer hoger, met een 10-jarig cumulatief risico van 3,4% bij mannen en 2,1% bij vrouwen. Hoewel de initiële ritmestoornis vaker shockable is, blijft de mortaliteit vergelijkbaar met die van niet-NIDCM-patiënten. Deze gegevens helpen cardiologen en huisartsen bij het inschatten van het risico op plotselinge hartdood en het afwegen van preventieve maatregelen zoals ICD-plaatsing bij deze specifieke hartfalenpopulatie.","abstract_original":"BACKGROUND: The incidence, risk and resuscitation characteristics of out-of-hospital-cardiac-arrest (OHCA) in the non-ischaemic dilated cardiomyopathy (NIDCM) population have not been analysed before in an unselected nationwide population, and could provide insight into risk stratification and prevention of sudden cardiac death in this unique heart failure cohort. METHODS: We conducted an observational, register-based study with cohort and nested case-control analyses using Denmark's healthcare registers between June 1, 2001 to December 31, 2022. DCM was classified as non-ischaemic using validated methods combined with exclusion of other causes of ischaemia or abnormal loading conditions. Incidence rates and hazard ratios were calculated in the general population. Absolute risk was determined using the Aalen-Johansen estimator in an exposure-matched cohort including incident NIDCM patients and matched controls. Resuscitation characteristics were determined in a nested case-control study. RESULTS: The incident rate of OHCA was approximately 12 times higher in NIDCM patients compared with the general population (incidence rate 532 vs 45 per 100,000 person years). The 5 and 10-year risk of OHCA for male de novo NIDCM patients was 2% and 3.4% respectively (vs 0.6% and 1.1% for non-NIDCM) and 1.4% and 2.1% for female de novo NIDCM patients (vs 0.4 and 0.5% for non-NIDCM). NIDCM OHCAs had higher rates of initial shockable rhythm than non-NIDCM OHCAs (48.5% vs 22.3%, p<0.001) but no significant differences in 30 day and 1 year mortality (79% vs 84% and 82% vs 84, respectively). CONCLUSION: The Danish NIDCM population has a significantly increased incidence of OHCA compared to the general population but a comparable mortality despite multiple positive resuscitation characteristics."}