{"id":"fbf607852598","type":"article","url":"https://hartvaat.nl/2026/08/10/urine-albumine-en-natrium-hebben-prognostische-waarde-bij-hartfalen-experimentel/","title":"Urine-albumine en natrium hebben prognostische waarde bij hartfalen — experimentele biomarkers nog onvoldoende onderbouwd","title_en":"Urinary Biomarkers for the Risk Assessment and Management of Heart Failure: Pearls and Pitfalls.","category":"hartfalen","category_label":"Hartfalen","professions":["cardioloog","internist"],"tags":[],"journal":"Current heart failure reports","doi":"10.1007/s11897-026-00774-9","source_url":"https://doi.org/10.1007/s11897-026-00774-9","authors":["Bethany Roehm","Yash Vaggar","Justin L Grodin","Robert D Toto"],"significance":5,"published":"2026-08-18","source_date":"2026-08-10","image":"https://hartvaat.nl/global/img/6cb8034713a3.webp","kennis":["https://hartvaat.nl/kennis/hartfalen/bnp-en-nt-probnp/","https://hartvaat.nl/kennis/diagnostiek/galectine-3-st2-hartfalen/"],"congress":"","summary_en":"This narrative review evaluates the clinical utility of urinary biomarkers in heart failure management. While urine albumin and sodium offer established prognostic and diagnostic value for guiding medication prioritization and diuretic therapy, experimental markers such as NGAL, KIM-1, and IGFBP7/TIMP-2 currently lack evidence of superior kidney injury prediction compared to serum creatinine. For clinical practice, this reinforces the role of routine urine parameters in cardiorenal risk stratification, while highlighting that novel biomarkers remain primarily of research and mechanistic interest at this time.","created":"2026-08-11T01:24:16Z","updated":"2026-08-11T01:24:19Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Deze review analyseert de klinische toepassing van urinebiomarkers bij patiënten met hartfalen. Hoewel urine-albumine en urine-natrium bewezen prognostische en diagnostische waarde hebben voor het stroomlijnen van medicatie en diureticabeheer, ontbreekt voor experimentele markers zoals NGAL en KIM-1 nog overtuigend bewijs van superieure risicoschatting ten opzichte van serumcreatinine. Voor de praktijk betekent dit dat gevestigde urineparameters nuttig zijn in het cardiorenale management, terwijl nieuwe markers momenteel vooral onderzoekswaarde hebben.","abstract_original":"PURPOSE OF REVIEW: We review potential applications and pitfalls of urinary biomarkers in people with heart failure (HF). RECENT FINDINGS: Albuminuria may indicate kidney damage and guide prioritization of medications in HF. Urine sodium is useful in guiding diuretic management. Several experimental urine biomarkers have been evaluated, with the most robust data available for neutrophil gelatinase-associated lipocalin, kidney injury marker 1, insulin-like growth factor-binding protein 7 in conjunction with tissue inhibitor of metalloproteinases-2, angiotensinogen, and N-acetyl-β-D-glucosaminidase. None provide diagnostic superiority over serum creatinine in evaluating risk of kidney injury. Some may have utility in identifying those at risk for adverse clinical outcomes. While urine albumin and sodium have prognostic and diagnostic utility in HF, the current role for other urine biomarkers is less clear, particularly in predicting worsening kidney function. Some of these biomarkers may provide mechanistic insights into kidney damage in HF."}