{"id":"7f5af9e720e8","type":"article","url":"https://hartvaat.nl/2026/08/10/voedingspatronen-en-macronutrientenvervanging-verlagen-triglyceriden-bij-hypertr/","title":"Voedingspatronen en macronutriëntenvervanging verlagen triglyceriden bij hypertriglyceridemie","title_en":"Dietary Interventions for Hypertriglyceridemia.","category":"cholesterol","category_label":"Cholesterol","professions":["cardioloog","huisarts","internist"],"tags":[],"journal":"Current atherosclerosis reports","doi":"10.1007/s11883-026-01444-w","source_url":"https://doi.org/10.1007/s11883-026-01444-w","authors":["Carol F Kirkpatrick","Kristina S Petersen","Penny M Kris-Etherton","Kevin C Maki"],"significance":5,"published":"2026-08-18","source_date":"2026-08-10","image":"https://hartvaat.nl/global/img/4444c1fb12db.webp","kennis":["https://hartvaat.nl/kennis/lipiden/fibraten-bij-hypertriglyceridemie/"],"congress":"","summary_en":"This narrative review outlines the pathophysiology of hypertriglyceridemia (HTG) and evaluates dietary strategies for its management. Guideline recommendations stress individualized dietary patterns based on triglyceride severity and underlying etiology, emphasizing partial carbohydrate replacement with unsaturated fats or protein, alongside limiting added sugars and alcohol. Combined with physical activity and weight management, these interventions form a cornerstone of cardioprotective lifestyle therapy. Clinicians can use these tailored dietary approaches to optimize lipid profiles and reduce cardiometabolic risk.","created":"2026-08-11T01:20:45Z","updated":"2026-08-11T01:20:49Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Deze review vat de pathofysiologie van hypertriglyceridemie (HTG) samen en evalueert het bewijs voor voedingstherapie. Richtlijnen benadrukken dat diëten op maat nodig zijn, afhankelijk van de ernst van de triglyceridespiegel en de onderliggende oorzaak. Geadviseerd wordt om koolhydraten gedeeltelijk te vervangen door onverzadigde vetten of eiwitten, alcohol en toegevoegde suikers te beperken, en te combineren met beweging en gewichtsverlies. Deze aanpak biedt een bewezen, cardioprotectieve basis voor de dagelijkse praktijk.","abstract_original":"PURPOSE OF REVIEW: This review summarizes the pathophysiology of hypertriglyceridemia (HTG) and describes the evidence for dietary interventions in the management of HTG. RECENT FINDINGS: HTG is most often caused by multiple triglyceride (TG)-raising gene variants. Rare monogenic disorders cause extreme HTG. Recommendations from dyslipidemia management guidelines emphasize that dietary interventions for HTG management should be tailored to the underlying causes and degree of TG elevation. Evidence-based cardioprotective dietary patterns can effectively reduce TG concentrations. The severity of TG elevation influences the level of restriction for intakes of foods/beverages with added sugars, alcoholic beverages, and total fat. Individual macronutrients impact TGs differently, with evidence supporting partial replacement of carbohydrates with unsaturated fatty acids, protein, or a combination for lowering the TG level. Physical activity is also a cornerstone of lifestyle intervention for HTG management. Weight loss for persons with overweight or obesity reduces TGs and can be achieved with dietary interventions, pharmacotherapy, and/or metabolic bariatric surgery, each of which may have a TG-lowering effect independent of weight loss."}