{"id":"0b1c0b70e8a8","type":"article","url":"https://hartvaat.nl/2026/08/20/long-covid-verhoogt-risico-op-hart-nier-en-longcomplicaties-trinetx-cohort/","title":"Long COVID verhoogt risico op hart-, nier- en longcomplicaties — TriNetX-cohort","title_en":"Cardiovascular, Renal, and Pulmonary Risks of Long COVID: A Retrospective Cohort Study Stratified by Age and Sex.","category":"chronische nierziekte","category_label":"Nierziekte","professions":["cardioloog","huisarts","internist"],"tags":[],"journal":"Journal of the American Heart Association","doi":"10.1161/JAHA.126.049226","source_url":"https://doi.org/10.1161/JAHA.126.049226","authors":["Akash Pradeep","Izola Ramalho","Martha L Carvour","Srija M Sivamurugan","Upinder Singh","Alejandro P Comellas","Sanjana Dayal"],"significance":5,"published":"2026-08-28","source_date":"2026-08-20","image":"","kennis":["https://hartvaat.nl/kennis/nierziekte/nierziekte-en-cardiovasculair-risico/","https://hartvaat.nl/kennis/cardiometabool/diabetes-type-1-en-hart/"],"congress":"","summary_en":"In a retrospective cohort of over 300,000 propensity-matched COVID-19 patients, Long COVID was associated with an elevated risk of cardiovascular, renal, and pulmonary complications. The relative risk was disproportionately higher in younger adults, particularly young women for cardiovascular and renal outcomes, and young men for pulmonary outcomes. These findings highlight the need for structured follow-up and risk-reduction strategies for Long COVID patients in routine clinical practice.","created":"2026-08-21T01:34:49Z","updated":"2026-08-21T01:34:49Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"In een retrospectief cohort van meer dan 300.000 gepaarde patiënten met COVID-19 bleek Long COVID geassocieerd met een verhoogd risico op cardiovasculaire, nier- en longcomplicaties. Het relatieve risico liep op bij jongere volwassenen, met name jonge vrouwen voor hart- en niercomplicaties en jonge mannen voor longcomplicaties. Deze bevindingen onderstreken het belang van structurele follow-up en risicomanagement voor deze patiëntengroep in de dagelijkse praktijk.","abstract_original":"BACKGROUND: A substantial proportion of patients with acute COVID-19 develop postacute sequelae of SARS-CoV-2 infection (Long COVID). The risk of adverse cardiovascular and related outcomes in Long COVID remains elusive. We hypothesized that individuals with Long COVID are at elevated risk for adverse cardiovascular, renal, and pulmonary (CRP) outcomes compared with those who recovered from COVID-19 without developing Long COVID. METHODS: We performed a retrospective cohort study using the global TriNetX network (>150 million patients). Adults with documented COVID-19 were classified by the presence/absence of clinically recognized Long COVID. We analyzed absolute risks and relative risks for 15 CRP outcomes, stratified by age (18-50, 51-64, ≥65 years). After excluding patients with preexisting outcomes of interest, propensity score matching was applied for age, sex, and common confounders. RESULTS: Among 2 613 432 adults identified with COVID-19 within TriNetX network, 315 612 matched individuals were included in the study. Long COVID was associated with higher risk of most CRP outcomes across all ages regardless of sex. Relative risks were disproportionately higher in younger adults, especially in young women for cardiovascular and renal outcomes and in young men for pulmonary outcomes. Findings remained directionally consistent across sensitivity analyses. Prior SARS-CoV-2 vaccination was not consistently associated with reduced CRP risk. CONCLUSIONS: Clinically recognized Long COVID was associated with increased risk of CRP outcomes, with relatively higher relative risks observed in younger adults. These findings support the need for continuing surveillance and risk-reduction strategies for cardiovascular and related disorders in Long COVID."}