{"id":"9b7b49d4bf8e","type":"article","url":"https://hartvaat.nl/2026/08/20/ouderlijke-obesitas-verhoogt-cardiorenale-risico-s-bij-nakomelingen-review/","title":"Ouderlijke obesitas verhoogt cardiorenale risico's bij nakomelingen — review","title_en":"Parental Obesity and Offspring Risk for Cardiorenal Diseases.","category":"chronische nierziekte","category_label":"Nierziekte","professions":["cardioloog","huisarts","internist"],"tags":[],"journal":"Current hypertension reports","doi":"10.1007/s11906-026-01379-2","source_url":"https://doi.org/10.1007/s11906-026-01379-2","authors":["Jussara M do Carmo","John E Hall","Zhen Wang","Alan J Mouton","Ana C M Omoto","Luciana Jorge","Alexandre A da Silva"],"significance":4,"published":"2026-08-28","source_date":"2026-08-20","image":"https://hartvaat.nl/global/img/94feed139c1f.webp","kennis":["https://hartvaat.nl/kennis/cardiometabool/obesitas-en-hart/","https://hartvaat.nl/kennis/nierziekte/nierziekte-en-cardiovasculair-risico/"],"congress":"","summary_en":"This narrative review examines evidence linking parental obesity, particularly maternal obesity, to an increased risk of cardiorenal and metabolic dysfunction in offspring. Emerging data suggest that intrauterine exposures, chronic inflammation, mitochondrial dysfunction, and altered intercellular signaling contribute to transgenerational disease programming. For clinical practice, these findings reinforce the importance of preconception counseling, weight management during pregnancy, and early-life interventions to mitigate long-term cardiovascular risk in the next generation.","created":"2026-08-21T01:31:55Z","updated":"2026-08-21T01:31:57Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Deze review synthetiseert het huidige bewijs dat ouderlijke obesitas, met name maternale obesitas, de kwetsbaarheid van nakomelingen voor cardiorenale en metabole aandoeningen verhoogt. Mechanismen zoals intrauteriene blootstelling, chronische ontsteking, mitochondriale dysfunctie en epigenetische veranderingen lijken een rol te spelen in deze transgenerationale overdracht. Voor de klinische praktijk onderstreept dit het cruciale belang van preventieve interventies rondom conceptie, zwangerschap en vroege kindjaren om het langetermijnrisico op hart- en vaatziekten bij de volgende generatie te beperken.","abstract_original":"PURPOSE OF REVIEW: Obesity rates have increased dramatically during the past four decades, and these increases have occurred in children and adolescents, as well as in adults at reproductive age. Currently, 40.3% of men and 39.7% of women 20-39 years of age in the United States are classified as obese, leading to a substantial rise in parental obesity. Obesity is a major risk factor for cardiovascular, metabolic and renal diseases, including hypertension, type 2 diabetes, and chronic kidney diseases. This review examines current evidence of how parental obesity programs offspring susceptibility to cardiorenal and metabolic dysfunction and discusses the potential underlying mechanisms that contribute to the long-term health consequences in the offspring. RECENT FINDINGS: Increasing evidence indicates that parental obesity, particularly maternal obesity, predisposes offspring to cardiovascular, metabolic, and renal dysfunction that can emerge early in life and persist into adulthood, even when controlled for lifestyle factors. Although alterations in the intrauterine and early postnatal environments are believed to underlie developmental programming, the mechanisms by which parental obesity influences long-term offspring health remain poorly understood. Emerging evidence suggests that dysregulation of neurohumoral pathways, chronic inflammation, mitochondrial dysfunction, and intercellular signaling may be transmitted across generations and contribute to increased risk of cardiorenal and metabolic diseases. Elucidating these mechanisms is essential for identifying novel therapeutic targets and determining whether interventions implemented before conception, during pregnancy, or during early life can mitigate adverse health outcomes and improve long-term offspring health."}