# Drinkfrequentie bepaalt HDL-C-niveau meer dan hoeveelheid per keer — Tromsø-studie

*geplaatst 2026-08-15 · Cholesterol · Alcohol (Fayetteville, N.Y.) · doi 10.1016/j.alcohol.2026.07.003 · https://hartvaat.nl/2026/09/01/drinkfrequentie-bepaalt-hdl-c-niveau-meer-dan-hoeveelheid-per-keer-troms-studie/*

In een cross-sectionele studie onder 18.614 volwassenen (40–79 jaar) bleek dat de frequentie van alcoholconsumptie sterker correleert met het HDL-C-gehalte dan de hoeveelheid per drankje. Elke extra gram alcohol per dag ging gepaard met een stijging van 0,005 mmol/L HDL-C, terwijl grote hoeveelheden per occasion vooral bij infrequente drinkers met een lager HDL-C werden geassocieerd. Deze bevindingen benadrukken dat drinkpatronen een rol spelen bij de interpretatie van HDL-C en cardiovasculair risicobeoordeling, zonder dat dit een aanleiding is om alcohol aan te raden voor preventie.

## English: The impact of drinking patterns on the relationship between alcohol use and levels of serum high-density lipoprotein cholesterol (HDL-C).

In a cross-sectional study of 18,614 adults (aged 40–79), the frequency of alcohol consumption showed a stronger positive association with HDL-C levels than the amount consumed per occasion. Each additional gram of alcohol per day was associated with a 0.005 mmol/L increase in HDL-C, whereas large amounts per drinking occasion were linked to lower HDL-C, particularly among infrequent drinkers. These findings highlight that drinking patterns influence HDL-C interpretation and cardiovascular risk assessment, though they do not support recommending alcohol for prevention.

## Abstract (original, from the publication)

Alcohol intake is known to influence serum high-density lipoprotein cholesterol (HDL-C), yet how drinking patterns shape this association is less researched. We examined whether frequency of drinking versus amount per occasion was differently related to HDL-C in a large population sample. Data were taken from a cross-sectional study of 18,614 respondents aged 40-79 years in the Tromsø general population health study. Alcohol use was assessed by self-report. Fasting HDL-C was measured using standardized laboratory protocols. Mean alcohol intake was 6.7 g/day and mean HDL-C 1.57 mmol/L. Total alcohol consumption correlated positively with HDL-C (r = 0.075; p < 0.001). In regression models, each additional gram/day was associated with an increase of 0.005 mmol/L HDL-C (95% CI 0.004-0.005; p < 0.001). Drinking frequency showed a positive correlation to HDL-C (r = 0.183; p < 0.001), whereas amount per occasion was inversely related to HDL-C (r = -0.128; p < 0.001). A significant frequency × amount interaction indicated that higher amounts per occasion were linked to lower HDL-C primarily among the infrequent drinkers (p < 0.001). The results indicate that the alcohol-HDL-C association was driven by how often alcohol was consumed rather than how much was consumed per occasion. Frequent, lower-dose drinking related to higher HDL-C, whereas infrequent, higher-dose occasions related to lower HDL-C. These findings underscore the need to consider drinking patterns, beyond average intake, when interpreting HDL-C and appraising alcohol-related cardiovascular risk.

Auteurs: Jørgen G Bramness, Jørg Mørland, Torgeir Gilje Lid, Anne Høye, Gudrun Høiseth

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Bron: Alcohol (Fayetteville, N.Y.), https://doi.org/10.1016/j.alcohol.2026.07.003. Bijgewerkt 2026-08-10T10:35:33Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.