{"id":"b277517fda21","type":"article","url":"https://hartvaat.nl/2026/09/01/pm2-5-blootstelling-versnelt-daling-van-egfr-bij-volwassenen/","title":"PM2.5-blootstelling versnelt daling van eGFR bij volwassenen","title_en":"Long Term Exposure to Ambient Particulate Matter","category":"chronische nierziekte","category_label":"Nierziekte","professions":["huisarts","internist"],"tags":[],"journal":"Kidney international reports","doi":"10.1016/j.ekir.2026.106693","source_url":"https://doi.org/10.1016/j.ekir.2026.106693","authors":["Siddhartha Mandal","Ram Jagannathan","Shuchi Anand","Mohammed K Ali","Poornima Prabhakaran","Sailesh Mohan","Ruby Gupta","K M Venkat Narayan","Viswanathan Mohan","Joel D Schwartz","Nikhil Tandon","Dorairaj Prabhakaran"],"significance":5,"published":"2026-08-24","source_date":"2026-09-01","image":"","kennis":["https://hartvaat.nl/kennis/nierziekte/wat-is-chronische-nierziekte/","https://hartvaat.nl/kennis/nierziekte/nsaids-en-nierziekte/"],"congress":"","summary_en":"In a longitudinal cohort of 12,271 adults from Chennai and Delhi (2010–2016), researchers examined the association between long-term ambient PM2.5 exposure and estimated glomerular filtration rate (eGFR). Each 5 μg/m³ increase in annual PM2.5 was significantly associated with a decline in eGFR (-0.32 ml/min/1.73m² in Chennai and -0.42 ml/min/1.73m² in Delhi). These findings highlight sustained air pollution as a key modifiable risk factor for progressive kidney dysfunction, underscoring the importance of environmental prevention strategies in chronic kidney disease management.","created":"2026-08-17T01:03:05Z","updated":"2026-08-17T01:03:05Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"In een cohort van 12.271 volwassenen in Chennai en Delhi (2010–2016) onderzochten wetenschappers de associatie tussen langdurige blootstelling aan fijnstof (PM2.5) en nierfunctie. Elke toename van 5 μg/m³ PM2.5 ging gepaard met een significante daling van de eGFR (-0,32 ml/min/1,73m² in Chennai en -0,42 ml/min/1,73m² in Delhi). Dit benadrukt dat chronische luchtverontreiniging een belangrijke modificeerbare risicofactor is voor nierfunctieverlies en onderstreept de noodzaak van milieuhygiënische preventie bij het beheer van chronische nierziekten.","abstract_original":"BACKGROUND: Despite epidemiological evidence linking fine particulate matter (PM2.5) to cardiometabolic diseases, links between PM2.5 and kidney function or chronic kidney disease (CKD) remain inconclusive. METHODS: In a population representative cohort of 12,271 adults (age ≥ 20 years) in 2 Indian cities (Chennai and Delhi), we investigated time-varying associations between annual average ambient PM2.5 and estimated glomerular filtration rates (eGFR) calculated using CKD-Epidemiology Collaboration (EPI) 2009 equations, at 3 time points during 2010 to 2016. Ambient PM2.5 exposures were assessed at residential geocodes using a national high-resolution spatiotemporal model for daily PM2.5 at 1 km × 1 km. City-specific linear mixed effect models were employed, incorporating inverse probability-based weighting to account for loss-to-follow-up. Effect modification by sex, waist-to-hip ratio, hypertension, and diabetes status were assessed using stratified models. RESULTS: Annual average PM2.5 at baseline and 2 follow-ups in Chennai were 33, 37, and 30 μg/m3 whereas those in Delhi were 118, 123, and 130 μg/m3. Median eGFRs at baseline were 112 ml/min per 1.73 m2 (interquartile range [IQR]: 101.9-121.0) in Chennai and 106.4 ml/min per 1.73 m2 (IQR: 94.4-116.6) in Delhi. Over time, a 5 ug/m3 increase in annual average PM2.5 was associated with a significant decline in eGFR in both cities as follows: -0.32 (95% confidence interval [CI]: -0.49 to -0.15) ml/min per 1.73 m2 in Chennai and -0.42 (95% CI: -0.57 to -0.27) ml/min per 1.73 m2 in Delhi. CONCLUSION: Annual average PM2.5 levels were associated with declines in eGFR. These data from a relatively young South Asian urban cohort underscore the need to further investigate the potential renal and cardiovascular impacts of sustained air pollution exposure."}