{"id":"f4ff0765d8c1","type":"article","url":"https://hartvaat.nl/2026/09/04/jonge-mi-patienten-hebben-meer-rook-en-ldl-afwijkingen-en-complexere-coronaanato/","title":"Jonge MI-patiënten hebben meer rook- en LDL-afwijkingen en complexere coronaanatomie","title_en":"Clinical, Inflammatory, and Angiographic Characteristics of Young, Middle-Aged, and Older Patients With Myocardial Infarction: A Single-Center Retrospective Study.","category":"chronische nierziekte","category_label":"Nierziekte","professions":["cardioloog","huisarts"],"tags":[],"journal":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","doi":"10.5543/tkda.2026.07150","source_url":"https://doi.org/10.5543/tkda.2026.07150","authors":["Halime Tanrıverdi","Emek Ediboğlu","Nurettin Yeral","Yeliz Sökmen","Sefa Nuri Akdemir","Elif Durak Ediboğlu"],"significance":4,"published":"2026-09-13","source_date":"2026-09-04","image":"","kennis":["https://hartvaat.nl/kennis/cardiometabool/diabetes-type-1-en-hart/","https://hartvaat.nl/kennis/nierziekte/nierziekte-en-cardiovasculair-risico/"],"congress":"","summary_en":"A retrospective single-center analysis of 905 acute myocardial infarction patients compared clinical, inflammatory, and angiographic profiles across three age groups (<45, 45–54, and ≥55 years). Patients under 45 had higher rates of smoking, elevated admission LDL cholesterol, greater thrombus burden, and more frequent bifurcation lesions, whereas hypertension, diabetes, and chronic kidney disease were less prevalent. These descriptive findings highlight the distinct risk profile of younger MI patients and underscore the need for earlier cardiovascular risk assessment and aggressive secondary prevention strategies.","created":"2026-09-06T01:07:14Z","updated":"2026-09-06T01:07:14Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Een retrospectieve single-center studie van 905 acute MI-patiënten vergeleek klinische, inflammatoire en angiografische kenmerken tussen drie leeftijdsgroepen (<45, 45–54 en ≥55 jaar). Jonge patiënten (<45 jaar) hadden vaker een rookgeschiedenis, hogere LDL-waarden bij opname, een hogere TIMI-thrombusbelasting en vaker bifurcatieletsels, terwijl hypertensie, diabetes en CKD minder voorkwamen. Deze beschrijvende bevindingen benadrukken de behoefte aan vroegere risicomanagement en intensieve secundaire preventie bij jonge MI-patiënten.","abstract_original":"OBJECTIVE: This study aimed to evaluate age-related differences in the clinical, inflammatory, and angiographic characteristics of patients with myocardial infarction (MI). METHOD: This retrospective, single-center observational study analyzed 905 consecutive patients with acute MI who underwent coronary angiography between February 2024 and April 2026. Patients were divided into three age groups: <45 years (n=96), 45-54 years (n=226), and ≥55 years (n=583). Demographic characteristics, cardiovascular risk factors, inflammatory indices, laboratory findings, and angiographic features were retrospectively analyzed. RESULTS: The mean age was 61.0+-13 years, and 71.2% of the patients were male. ST-segment elevation myocardial infarction was present in 59.4% of young patients. Young patients had a higher prevalence of ever smoking, higher admission low-density lipoprotein cholesterol levels, a higher prevalence of high TIMI thrombus burden, and more frequent bifurcation lesions. In contrast, hypertension, diabetes mellitus, chronic kidney disease, and previous coronary artery disease were less common among young patients. Exploratory multinomial logistic regression analyses identified fewer statistically significant adjusted associations when comparing patients aged 45-54 years with those aged <45 years than when comparing patients aged ≥55 years with those aged <45 years. CONCLUSION: Age-related differences were observed in the clinical, inflammatory, and angiographic characteristics of patients with MI, with fewer between-group differences between young and middle-aged patients than between young and older patients. These findings represent descriptive associations derived from a retrospective, single-center observational study and should not be interpreted as causal."}