# Verlaagde spierkracht en balans correleren met hoger NT-proBNP bij CKD-patiënten

*geplaatst 2026-09-23 · Nierziekte · Journal of nephrology · doi 10.1093/joneph/aajag036 · https://hartvaat.nl/2026/09/15/verlaagde-spierkracht-en-balans-correleren-met-hoger-nt-probnp-bij-ckd-patienten/*

Een cross-sectionele studie onder 113 niet-dialyse CKD-patiënten onderzocht de relatie tussen fysieke prestaties en serum-NT-proBNP. Na correctie voor leeftijd, nierfunctie en medicatie bleek een verminderde spierkracht en balans significant samen te hangen met verhoogde NT-proBNP-waarden. Dit bevestigt dat fysieke beperkingen een klinisch bruikbaar signaal kunnen zijn voor onderliggend hartfalenrisico of cardiovasculaire stress bij nierpatiënten, wat aanvullende cardiorenale screening kan rechtvaardigen.

## English: Serum N-terminal pro-B-type natriuretic peptide and physical performance in middle-aged and older patients with chronic kidney disease.

A cross-sectional study of 113 non-dialysis CKD patients examined the relationship between physical performance and serum NT-proBNP. After adjusting for age, renal function, and medications, reduced muscle strength and balance were significantly associated with elevated NT-proBNP levels. This confirms that physical limitations may serve as a practical bedside marker for underlying cardiovascular stress or heart failure risk in CKD, potentially guiding more targeted cardiorenal screening.

## Abstract (original, from the publication)

BACKGROUND: Observational studies have reported that impaired physical performance is associated with an elevated risk for cardiovascular disease (CVD) in patients with non-dialysis chronic kidney disease (CKD). However, there is limited evidence supporting this finding from a pathological perspective. As such, the present study aimed to determine the association between physical performance variables and serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels, a biomarker for estimating CVD risk, in patients with non-dialysis CKD. METHODS: This cross-sectional study involved 113 middle-aged and older patients with CKD (mean [ ± SD] age, 66 ± 9 years; 50.4% women). We evaluated serum NT-proBNP levels, handgrip strength, knee extension strength, 30-second chair stand test, maximal gait speed, 60-second single-leg stance test, and sit-and-reach tests. RESULTS: Decreased handgrip strength, knee extension strength, and 60-second single-leg stance score were associated with elevated serum NT-proBNP levels after adjusting for age, sex, hypertension, diabetes, dyslipidemia, body mass index, urinary albumin-to-creatinine ratio, estimated glomerular filtration rate, medication use (ie, diuretic use, β-blocker use, renin-angiotensin system inhibitor use), and physical activity level (all P < .05). Moreover, stepwise regression analysis revealed that the score for completion of the 60-second single-leg stance test was selected as a covariate of serum NT-proBNP levels, even after adjusting for muscle strength variable. CONCLUSIONS: Results of this study suggest that attenuated muscle strength and balance function tend to be associated with higher serum NT-proBNP levels in patients with non-dialysis CKD, which expands previous observational findings.

Auteurs: Riri Kobayashi, Shoya Mori, Shun Yoshikoshi, Masahiro Matsui, Chie Saito, Seiji Maeda, Makoto Kuro-O, Kunihiro Yamagata, Keisei Kosaki

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Bron: Journal of nephrology, https://doi.org/10.1093/joneph/aajag036. Bijgewerkt 2026-09-16T01:26:24Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.