{"id":"2e9400edc3f3","type":"article","url":"https://hartvaat.nl/2026/09/18/savr-ozaki-en-tavi-bij-aortastenose-vergelijkbare-vroege-uitkomsten-ozaki-toont-/","title":"SAVR, Ozaki en TAVI bij aortastenose: vergelijkbare vroege uitkomsten, Ozaki toont gunstigere hemodynamiek op 6 maanden","title_en":"Early clinical and hemodynamic outcomes of SAVR, Ozaki neocuspidization, and TAVI: A real-world observational study.","category":"chronische nierziekte","category_label":"Nierziekte","professions":["cardioloog"],"tags":[],"journal":"Medicine","doi":"10.1097/MD.0000000000050738","source_url":"https://doi.org/10.1097/MD.0000000000050738","authors":["Safa Özçelik","Semih Eren","Kemal Özdemir","Ferdi Peynirci","Yasin Özden","Yavuz Şensöz","Sait Terzi","İlyas Kayacioğlu"],"significance":4,"published":"2026-09-27","source_date":"2026-09-18","image":"https://hartvaat.nl/global/img/6e2cc0469790.webp","kennis":["https://hartvaat.nl/kennis/cardiometabool/peripartum-cardiomyopathie/","https://hartvaat.nl/kennis/nierziekte/sglt2-nierbescherming-mechanisme/"],"congress":"","summary_en":"A retrospective single-center study (n=153) compared early clinical and 6-month hemodynamic outcomes of SAVR, the Ozaki procedure, and TAVI in patients with severe aortic stenosis. No significant differences were observed in early mortality, stroke, or dialysis requirements, though TAVI was associated with a higher rate of permanent pacemaker implantation. At 6 months, the Ozaki group demonstrated more favorable hemodynamic parameters, but these findings remain hypothesis-generating due to the small cohort, incomplete follow-up, and observational design. Larger prospective trials are needed to establish comparative safety and durability.","created":"2026-09-20T01:28:20Z","updated":"2026-09-20T01:28:22Z","licence":"Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.","body_markdown":"Een retrospectieve single-center studie (n=153) vergeleek de vroege klinische en 6-maandse hemodynamische uitkomsten van SAVR, de Ozaki-procedure en TAVI bij patiënten met ernstige aortastenose. Er waren geen significante verschillen in vroege mortaliteit, beroerte of dialysebehoefte, hoewel TAVI vaker gepaard ging met permanente pacemakerimplantatie. Op 6 maanden vertoonde de Ozaki-groep gunstigere hemodynamische parameters, maar vanwege de beperkte steekproef, onvolledige follow-up en retrospectieve opzet blijven deze bevindingen hypothese-genererend. De studie benadrukt dat grotere prospectieve onderzoeken nodig zijn om de veiligheid en duurzaamheid van deze interventies te bevestigen.","abstract_original":"Aortic stenosis is a common valvular heart disease associated with substantial morbidity and mortality if left untreated. Surgical aortic valve replacement (SAVR), transcatheter aortic valve implantation (TAVI), and autologous pericardial aortic valve reconstruction (Ozaki procedure) represent alternative interventional strategies, but direct real-world comparisons remain limited. This study evaluated early clinical and 6-month hemodynamic outcomes following these 3 treatment approaches. This retrospective single-center observational study included 153 consecutive patients with severe aortic stenosis treated between December 2020 and March 2022 (SAVR, n = 67; Ozaki, n = 31; TAVI, n = 55). Early mortality was the primary clinical outcome, and 6-month mean transvalvular gradient was the primary echocardiographic outcome. Other clinical and echocardiographic outcomes were considered secondary or exploratory. Multivariable regression, analysis of covariance, and separate pairwise propensity-score matching models were used to account for baseline differences. Propensity scores were estimated using age, sex, EuroSCORE II, chronic kidney disease, and coronary artery disease. TAVI patients were older and had higher operative risk. No statistically significant differences were detected among the groups in early mortality, stroke, or postoperative dialysis. Permanent pacemaker implantation was more frequent after TAVI, while prolonged intensive care unit stay also differed among treatment groups. At 6 months, the Ozaki group showed favorable hemodynamic parameters, including lower mean transvalvular gradients and maximum transvalvular velocity. However, 6-month echocardiographic follow-up was incomplete, and these findings should be considered exploratory given the small Ozaki cohort, baseline differences, and observational study design. SAVR, Ozaki neocuspidization, and TAVI showed distinct early clinical and hemodynamic profiles in this real-world observational cohort. No statistically significant differences were detected in several major early clinical outcomes, although the study was not sufficiently powered to establish equivalent safety or exclude clinically meaningful differences. The favorable short-term hemodynamic findings observed with the Ozaki procedure should be considered hypothesis-generating. Larger prospective studies with longer follow-up are needed to further evaluate comparative clinical outcomes, hemodynamic performance, and durability."}