# TyG-BMI correleert met versnelde vaatveroudering bij jongere volwassenen

*geplaatst 2026-10-05 · Cholesterol · BMC cardiovascular disorders · doi 10.1186/s12872-026-06239-0 · https://hartvaat.nl/2026/09/25/tyg-bmi-correleert-met-versnelde-vaatveroudering-bij-jongere-volwassenen/*

Deze cross-sectionele studie onderzocht de relatie tussen de TyG-BMI (een surrogaat voor insulineresistentie) en vroege vaatveroudering (EVA), gedefinieerd via baPWV, bij 1.272 Chinese volwassenen van 30-59 jaar. Een stijging van 10 eenheden in de TyG-BMI ging gepaard met een 14,9% hoger risico op EVA (OR 1,149; 95% BI 1,083-1,231), met een niet-lineair verloop rond een drempelwaarde van 210,98. De bevindingen suggereren dat TyG-BMI een eenvoudig en toegankelijk screeningsinstrument kan zijn voor het inschatten van vaatverouderingsrisico in deze populatie, hoewel externe validatie nodig is.

## English: Association between the triglyceride-glucose-body mass index and the risk of early vascular aging in young and middle-aged Chinese adults: a cross-sectional study.

This cross-sectional study examined the association between the TyG-BMI index (a surrogate for insulin resistance) and early vascular aging (EVA), defined by brachial-ankle pulse wave velocity, in 1,272 Chinese adults aged 30–59 years. Each 10-unit increase in TyG-BMI was associated with a 14.9% higher risk of EVA (OR 1.149; 95% CI 1.083–1.231), with a nonlinear relationship observed around a threshold of 210.98. The findings suggest TyG-BMI could serve as a simple, accessible tool for estimating vascular aging risk in this demographic, pending external validation.

## Abstract (original, from the publication)

BACKGROUND: Early vascular aging (EVA) reflects accelerated arterial aging and is increasingly recognized as an important precursor of cardiovascular disease (CVD). Insulin resistance (IR) has been implicated in the pathogenesis of vascular aging. The triglyceride-glucose-body mass index (TyG-BMI), a surrogate marker of IR, has demonstrated predictive value for several cardiometabolic disorders. However, evidence regarding its association with EVA remains limited. METHODS: This cross-sectional study enrolled 1,272 Chinese adults aged 30 ~ 59 years who completed brachial-ankle pulse wave velocity (baPWV) measurement. EVA was defined as a baPWV value above the 90th percentile in the corresponding 10-year age group. Multivariable logistic regression models were applied to assess the association between TyG-BMI and EVA. Restricted cubic spline (RCS) analysis was conducted to explore the potential nonlinear relationship. Additional analyses further examined the associations of TyG-BMI with baPWV and Framingham risk score (FRS)-derived indicators. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive ability of TyG-BMI for EVA. RESULTS: After full adjustment, each 10-unit increase in TyG-BMI was associated with a 14.9% increased risk of EVA (odds ratio [OR] 1.149, 95% confidence interval [CI] 1.083~1.231). RCS analysis revealed a nonlinear association between TyG-BMI and EVA, with a turning point at a TyG-BMI value of 210.98. TyG-BMI also showed a nonlinear association with baPWV and FRS-derived indicators (predicted vascular age, age gap, and predicted 10-year CVD risk). In the fully adjusted model incorporating TyG-BMI, the area under the curve (AUC) for identifying EVA was 0.8533. CONCLUSIONS: This cross-sectional study demonstrated that TyG-BMI was independently and nonlinearly associated with EVA among young and middle-aged Chinese adults. The observed turning point suggests a potential reference point for this association. These findings suggest that TyG-BMI may serve as a simple, readily accessible indicator for assessing EVA risk in this population, pending external validation.

Auteurs: Chaomin Kong, Caixia Lyu, Wenjin Lu, Xuedong Bai, Hongyang Dong, Feifei Zhang, Lixia Yao, Shuchun Chen

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Bron: BMC cardiovascular disorders, https://doi.org/10.1186/s12872-026-06239-0. Bijgewerkt 2026-09-28T01:21:55Z. Citeer vrij, met bronvermelding en een link naar hartvaat.nl (de url van het record). Samenvattingen zijn redactioneel werk van HartVaat; de oorspronkelijke publicaties blijven van hun uitgevers (doi). Geen medisch advies.